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Antimicrobial Activity of Tebipenem and Comparators against Enterobacterales from diverse Outpatient Centers and Nursing Homes in the United States

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2023; 61 (3)

Introduction: Tebipenem is a potential option for the treatment of a range of infections because of its oral dosing coupled with the safety profile of......

ICEGpa1804, a novel integrative and conjugative element carrying eight resistance genes, identified in Glaesserella parasuis

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2023; 61 (4)

ICEGpa1804 was identified in the genome of a serovar 2, ST279 isolate EHP1804 carrying eight different resistance genes from 200 Glaesserella parasuis......

Serum concentration of continuously administered vancomycin influences efficacy and safety in critically ill adults: a systematic review

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2023; 62 (6)

Objectives: Vancomycin is used to treat Gram-positive infections in critically ill adults. For vancomycin administered by continuous infusion (CI), va......

Nafcillin Augmentation of Daptomycin and Cathelicidin LL-37 Killing of Methicillin-resistant Staphylococcus epidermidis: Foundations of Successful Therapy of Endocarditis

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2023; 61 (6)

Methicillin-resistant Staphylococcus epidermidis (MRSE) endocarditis failing conventional therapy has been successfully treated with nafcillin plus da......

Putative transmission of extended-spectrum β-lactamase-producing Escherichia coli among men who have sex with men in Amsterdam, the Netherlands

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2023; 62 (1)

Objectives: A previous study showed higher prevalence of Escherichia coli ( E. coli) expressing extended -spectrum beta-lactamases (ESBL-Ec) among men......

Real-world effectiveness of ceftazidime/avibactam versus polymyxin B in treating patients with carbapenem-resistant Gram-negative bacterial infections

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2023; 62 (2)

Objectives: To compare the effectiveness of ceftazidime/avibactam (CAZ/AVI) and polymyxin B against carbapenem-resistant Gram-negative bacteria (CRGNB......

Prospective role of cefiderocol in the management of carbapenem-resistant Acinetobacter baumannii infections: Review of the evidence

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2023; 62 (2)

Carbapenem-resistant Acinetobacter baumannii (CRAB) has been classified by the World Health Organization as being in the critical category of pathogen......

Treatment success of rescue regimens after dual therapy failure in people living with HIV in a real-life setting

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2023; 62 (2)

Objectives: Few data on management of two-drug regimen (2DR) failure in people living with HIV (PLWH) are available. Methods: Retrospective study of t......

Impairment of novel non-coding small RNA00203 inhibits biofilm formation and reduces biofilm-specific antibiotic resistance in Acinetobacter baumannii

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2023; 62 (3)

Small RNAs (sRNAs) are post-transcriptional regulators of many biological processes in bacteria, includ-ing biofilm formation and antibiotic resistanc......

Model-informed dose optimisation of polymyxin-rifampicin combination therapy against multidrug-resistant Acinetobacter baumannii

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2023; 62 (3)

Objectives: Antimicrobial resistance is a major global threat. Because of the stagnant antibiotic pipeline, synergistic antibiotic combination therapy......

Activity of polymyxin B combinations against genetically well-characterised Klebsiella pneumoniae producing NDM-1 and OXA-48-like carbapenemases

期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2023; 62 (5)

Background: Combination therapy can enhance the activity of available antibiotics against multidrug-resistant Gram-negative bacteria. This study asses......

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