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Construction of a reference material panel for detecting KRAS/NRAS/EGFR/BRAF/MET mutations in plasma ctDNA

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2021; 74 (5)

Background The absence of high-quality next-generation sequencing (NGS) reference material (RM) has impeded the clinical use of liquid biopsies with p......

COVID-19 salivary signature: diagnostic and research opportunities

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2021; 74 (6)

The COVID-19 (caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) epidemic started in Wuhan (Hubei Province, China) in mid-Decembe......

Histopathological features of multiorgan percutaneous tissue core biopsy in patients with COVID-19

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2021; 74 (8)

Aims The global outbreak of COVID-19 has resulted in an increased mortality. However, whether severe acute respiratory syndrome coronavirus 2 (SARS-Co......

Nek9,a sensitive immunohistochemical marker for Schwannian, melanocytic and myogenic tumours

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2021; 74 (6)

Aims In our previous study, striking Nek9 staining was observed in peripheral nerves for the first time. Therefore, in the current study, we aimed to ......

Role of PRPS2 as a prognostic and therapeutic target in osteosarcoma

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2021; 74 (5)

Aims Osteosarcoma (OS) is the most common primary malignant tumour of the bone. However, further improvement in survival has not been achieved due to ......

Expression of YAP1 and pSTAT3-S727 and their prognostic value in glioma

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2021; 74 (8)

Aims A growing research demonstrated that YAP1 played important roles in gliomagenesis. We explored the expression of YAP1 and STAT3, the relationship......

Diagnostic approach in TFE3-rearranged renal cell carcinoma: a multi-institutional international survey

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2021; 74 (5)

Transcription factor E3-rearranged renal cell carcinoma (TFE3-RCC) has heterogenous morphologic and immunohistochemical (IHC) features. 131 pathologis......

Identification of potential crucial genes associated with the pathogenesis and prognosis of liver hepatocellular carcinoma

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2021; 74 (8)

Aims Liver hepatocellular carcinoma (LIHC) is the main manifestation of primary liver cancer, with low survival rate and poor prognosis. Medical decis......

Mutation spectrum and erythrocyte indices characterisation of alpha-thalassaemia and beta-thalassaemia in Sichuan women in China: a thalassaemia screening survey of 42 155 women

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2021; 74 (3)

Aims The present study aims to investigate the mutation spectrum of thalassaemia, and characterise the erythrocyte indices of thalassaemia in a large ......

Xp11 translocation renal cell carcinoma with morphological features mimicking multilocular cystic renal neoplasm of low malignant potential: a series of six cases with molecular analysis

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2021; 74 (3)

Aims Xp11 translocation renal cell carcinoma (RCC) is a distinctive subtype of RCC with TFE3 (Transcription Factor Binding to IGHM Enhancer 3) gene re......

Abnormal expression of p-ATM/CHK2 in nasal extranodal NK/T cell lymphoma, nasal type, is correlated with poor prognosis

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2021; 74 (4)

Aims The aim of this study is to investigate the expression profiles of cell cycle related proteins in nasal extranodal NK/T cell lymphoma, nasal type......

Improving equivalence in fibrinogen evaluation between the prothrombin time-derived fibrinogen assay and Clauss method using a pooled plasma calibrator

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2021; 74 (1)

Aims Both the Clauss and prothrombin time-derived fibrinogen (PT-Fib) methods have widely been used in fibrinogen (Fib) evaluation. We aimed to improv......

Compound heterozygous mutations identified in severe type I protein S deficiency impaired the secretion of protein S

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2020; 73 (1)

Aims Hereditary protein S (PS) deficiency is one of the natural anticoagulant deficiencies causing thrombophilia. We herein described a young male wit......

Characteristics, behaviour and role of biomarkers in metastatic triple-negative breast cancer

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2020; 73 (3)

Aims Characterising the factors responsible for metastatic triple-negative breast cancer (TNBC) is of significant importance, considering its high mor......

Overexpression of EI2BL promoted human non-small cell lung cancer progression by inducing cell EMT phenotype

期刊: JOURNAL OF CLINICAL PATHOLOGY, 2020; 73 (3)

Aims To unveil the role of EI2BL in non-small cell lung cancer (NSCLC) and the relationship between expression of EI2BL and the prognosis of patients ......

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