期刊： BRIEFINGS IN BIOINFORMATICS, 2023; 24 (1)
Analysis of the methylome of tumor cell -free deoxyribonucleic acid (DNA; cfDNA) has emerged as a powerful non-invasive technique for cancer subtyping......
期刊： BRIEFINGS IN BIOINFORMATICS, 2023; 24 (2)
Alignment is the cornerstone of many long-read pipelines and plays an essential role in resolving structural variants (SVs). However, forced alignment......
期刊： BRIEFINGS IN BIOINFORMATICS, 2023; 24 (5)
Factor analysis, ranging from principal component analysis to nonnegative matrix factorization, represents a foremost approach in analyzing multi-dime......
期刊： BRIEFINGS IN BIOINFORMATICS, 2023; 24 (6)
Computational reproducibility is a simple premise in theory, but is difficult to achieve in practice. Building upon past efforts and proposals to maxi......
期刊： BRIEFINGS IN BIOINFORMATICS, 2023; 24 (3)
The expanding field of epitranscriptomics might rival the epigenome in the diversity of biological processes impacted. In recent years, the developmen......
期刊： BRIEFINGS IN BIOINFORMATICS, 2023; 24 (2)
Discovering pre-microRNAs (miRNAs) is the core of miRNA discovery. Using traditional sequence/structural features, many tools have been published to d......
期刊： BRIEFINGS IN BIOINFORMATICS, 2023; 24 (2)
Solubility is a property of central importance for the use of proteins in research in molecular and cell biology and in applications in biotechnology ......
期刊： BRIEFINGS IN BIOINFORMATICS, 2023; 24 (3)
Motivation: Interpretability has become a necessary feature for machine learning models deployed in critical scenarios, e.g. legal system, healthcare.......
期刊： BRIEFINGS IN BIOINFORMATICS, 2023; 24 (4)
Classifying epitopes is essential since they can be applied in various fields, including therapeutics, diagnostics and peptide-based vaccines. To dete......
期刊： BRIEFINGS IN BIOINFORMATICS, 2023; 24 (4)
In only a few years, as a breakthrough technology, clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas) ge......
期刊： BRIEFINGS IN BIOINFORMATICS, 2023; 24 (1)
Due to the increasing importance of graphs and graph streams in data representation in today's era, concept drift detection in graph streaming scenari......
期刊： BRIEFINGS IN BIOINFORMATICS, 2023; 24 (1)
We draw from the assumption that similarities between pathogens at both pathogen protein and host protein level, may provide the appropriate framework......
期刊： BRIEFINGS IN BIOINFORMATICS, 2023; 24 (1)
In epistasis analysis, single -nucleotide polymorphism-single -nucleotide polymorphism interactions (SSIs) among genes may, alongside other environmen......
期刊： BRIEFINGS IN BIOINFORMATICS, 2023; 24 (4)
Three-dimensional (3D) genome architecture is characterized by multi-scale patterns and plays an essential role in gene regulation. Chromatin conforma......
