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Comparative Proteomics Reveals Prolonged Corneal Preservation Impaired Ocular Surface Immunity Accompanied by Fibrosis in Human Stroma

期刊: JOURNAL OF PROTEOME RESEARCH, 2023; 22 (12)

Cornea transplantation is one of the most commonly performed allotransplantations worldwide. Prolonged storage of donor corneas leads to decreased end......

Simultaneous Quantification of Apolipoprotein C-III O-Glycoforms by Protein-MRM

期刊: JOURNAL OF PROTEOME RESEARCH, 2023; 22 (1)

Apolipoprotein C-III (APOC-III) regulates triglyceride levels, associated with a risk of cardiovascular disease. One gene generates several proteoform......

Exploring High-Throughput Immunoassays for Biomarker Validation in Rheumatic Diseases in the Context of the Human Proteome Project

期刊: JOURNAL OF PROTEOME RESEARCH, 2023; 22 (4)

Rheumatic diseases are high prevalence pathologies with different etiology and evolution and low sensitivity in clinical diagnosis. Therefore, it is n......

Lipidomic and Metallomic Alteration of Caenorhabditis elegans after Acute and Chronic Manganese, Iron, and Zinc Exposure with a Link to Neurodegenerative Disorders

期刊: JOURNAL OF PROTEOME RESEARCH, 2023; ()

Parkinson's disease (PD) progresses with the loss of dopaminergic neurons in the substantia nigra pars compacta region of the brain. The superior mech......

Automated Proteomics Workflows for High-Throughput Library Generation and Biomarker Detection Using Data-Independent Acquisition

期刊: JOURNAL OF PROTEOME RESEARCH, 2023; 22 (6)

Sequentialwindow acquisition of all theoretical mass spectra-massspectrometry underpinned by advanced bioinformatics offers a frameworkfor comprehensi......

Direct Mass Spectrometry-Based Detection and Antibody Sequencing of Monoclonal Gammopathy of Undetermined Significance from Patient Serum: A Case Study

期刊: JOURNAL OF PROTEOME RESEARCH, 2023; 22 (9)

Monoclonal gammopathyof undetermined significance (MGUS) is aplasma cell disorder characterized by the presence of a predominantmonoclonal antibody (i......

Tumor Lipid Signatures Are Descriptive of Acquisition of Therapy Resistance in an Endocrine-Related Breast Cancer Mouse Model

期刊: JOURNAL OF PROTEOME RESEARCH, 2023; ()

The lipid metabolism adaptations of estrogen and progesteronereceptor-positivebreast cancer tumors from a mouse syngeneic model are investigatedin rel......

Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent

期刊: JOURNAL OF PROTEOME RESEARCH, 2023; 22 (11)

Lung cancer (LC) is a leading cause of mortality, claiming more than 1.8 million deaths per year worldwide. Surgery is one of the most effective treat......

Proteome Decomplexation of Trimeresurus erythrurus Venom from Mizoram, India

期刊: JOURNAL OF PROTEOME RESEARCH, 2023; 22 (1)

Green pit vipers are the largest group of venomous vipers in tropical and subtropical Asia, which are responsible for most of the bite cases across th......

IQMMA: Efficient MS1 Intensity Extraction Pipeline Using Multiple Feature Detection Algorithms for DDA Proteomics

期刊: JOURNAL OF PROTEOME RESEARCH, 2023; 22 (9)

One of the key steps in data dependent acquisition (DDA)proteomicsis detection of peptide isotopic clusters, also called features,in MS1 spectra and m......

Digital Microfluidics for Microproteomic Analysis of Minute Mammalian Tissue Samples Enabled by a Photocleavable Surfactant

期刊: JOURNAL OF PROTEOME RESEARCH, 2023; 22 (10)

Proteome profiles of precious tissue samples have great clinical potential for accelerating disease biomarker discovery and promoting novel strategies......

Multiomics Reveals Induction of Neuroblastoma SK-N-BE(2)C Cell Death by Mitochondrial Division Inhibitor 1 through Multiple Effects

期刊: JOURNAL OF PROTEOME RESEARCH, 2023; 23 (1)

Mitochondrial division inhibitor 1 (Mdivi-1) is a well-known synthetic compound aimed at inhibiting dynamin-related protein 1 (Drp1) to suppress mitoc......

COL1A2 Barcoding: Bone Species Identification via Shotgun Proteomics

期刊: JOURNAL OF PROTEOME RESEARCH, 2023; 23 (1)

Species identification of fragmentary bones remains a challenging task in archeology and forensics. A species identification method for such fragmenta......

UHPLC-MS/MS-Based Identity Confirmation of Amino Acids Involved in Response to and Side Effects from Antiseizure Medications

期刊: JOURNAL OF PROTEOME RESEARCH, 2023; 22 (3)

Real-time breath analysis using secondary electro-spray ionization coupled with high-resolution mass spectrometry is a fast and noninvasive method to ......

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