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Meta-analysis of short- and long-term efficacy of mononuclear cell transplantation in patients with myocardial infarction

期刊: AMERICAN HEART JOURNAL, 2020; 220 ()

Background Mononuclear cells (MNCs) have been tested in clinical trials across multiple cardiovascular pathologies with mixed results. Major adverse c......

Average daily ischemic versus bleeding risk in patients with ACS undergoing PCI: Insights from the BleeMACS and RENAMI registries

期刊: AMERICAN HEART JOURNAL, 2020; 220 ()

Background The risk of recurrent ischemia and bleeding after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) may vary durin......

Outcome impact of different tranexamic acid regimens in cardiac surgery with cardiopulmonary bypass (OPTIMAL): Rationale, design, and study protocol of a multicenter randomized controlled trial

期刊: AMERICAN HEART JOURNAL, 2020; 222 ()

Background Tranexamic acid (TxA) reduces perioperative blood transfusion in cardiac surgery; however, the optimal dose of TxA remains unknown. Methods......

Implementation of Best Practices-Developing and Optimizing Regional Systems of Stroke Care: Design and Methodology

期刊: AMERICAN HEART JOURNAL, 2020; 222 ()

The AHA Guidelines recommend developing multi-tiered systems for the care of patients with acute stroke.' An ideal stroke system of care should ensure......

Quantitative flow ratio-guided strategy versus angiography-guided strategy for percutaneous coronary intervention: Rationale and design of the FAVOR III China trial

期刊: AMERICAN HEART JOURNAL, 2020; 223 ()

Background Quantitative flow ratio (QFR) is a novel angiography-based approach enabling fast computation of fractional flow reserve without use of pre......

Effect on thromboprophylaxis among hospitalized patients using a system-wide multifaceted quality improvement intervention: Rationale and design for a multicenter cluster randomized clinical trial in China

期刊: AMERICAN HEART JOURNAL, 2020; 225 ()

Background Venous thromboembolism (VTE) is a life-threatening disease that can affect each hospitalized patient. But the current in-hospital thrombopr......

Randomized trial of argatroban plus recombinant tissue-type plasminogen activator for acute ischemic stroke (ARAIS): Rationale and design

期刊: AMERICAN HEART JOURNAL, 2020; 225 ()

Background Previous studies have implied the efficacy and safety of argatroban plus recombinant tissue-type plasminogen activator (r-tPA) in patients ......

Impact of salt substitute and stepwise reduction of salt supply on blood pressure in residents in senior residential facilities: Design and rationale of the DECIDE-Salt trial

期刊: AMERICAN HEART JOURNAL, 2020; 226 ()

Background High sodium intake has been considered as the leading dietary risk factor for deaths and disability-adjusted life-years among older adults.......

PROVIDE-HF primary results: Patient-Reported Outcomes inVestigation following Initiation of Drug therapy with Entresto (sacubitril/valsartan) in heart failure

期刊: AMERICAN HEART JOURNAL, 2020; 230 ()

Background In PARADIGM-HF, sacubitril/valsartan improved quality of life (QOL) versus enalapril in heart failure with reduced ejection fraction (HFrEF......

A multinational registry to study the characteristics and outcomes of heart failure patients: The global congestive heart failure (G-CHF) registry

期刊: AMERICAN HEART JOURNAL, 2020; 227 ()

Aims The goal of the global congestive heart failure (G-CHF) registry is to collect comparative international data on heart failure characteristics, m......

China Tongxinluo Study for myocardial protection in patients with Acute Myocardial Infarction (CTS-AMI): Rationale and design of a randomized, double-blind, placebo-controlled, multicenter clinical trial

期刊: AMERICAN HEART JOURNAL, 2020; 227 ()

Background Acute ST-segment elevation myocardial infarction (STEMI) remains a serious life-threatening event. Despite coronary revascularization, pati......

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