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The role of dorsomedial striatum adenosine 2A receptors in the loss of goal-directed behaviour

期刊: PSYCHOPHARMACOLOGY, 2023; 240 (3)

Rationale Adenosine A(2A) receptors (A(2A)R) in the dorsal striatum have been implicated in goal-directed behaviour. While activation of these recepto......

Lipopolysaccharide-induced endotoxaemia during adolescence promotes stress vulnerability in adult mice via deregulation of nuclear factor erythroid 2-related factor 2 in the medial prefrontal cortex

期刊: PSYCHOPHARMACOLOGY, 2023; 240 (4)

RationaleSepsis is a severe inflammatory response to infection that leads to long-lasting cognitive impairment and depression after resolution. The li......

Clozapine but not lithium reverses aberrant tyrosine uptake in patients with bipolar disorder

期刊: PSYCHOPHARMACOLOGY, 2023; 240 (8)

RationaleAvailability of the dopamine and noradrenaline precursor tyrosine is critical for normal functioning, and deficit in tyrosine transport acros......

Sex-dependent divergence in the effects of GLP-1 agonist exendin-4 on alcohol reinforcement and reinstatement in C57BL/6J mice

期刊: PSYCHOPHARMACOLOGY, 2023; 240 (6)

RationaleAlcohol use disorder remains a leading cause of preventable deaths, and current treatments have limited efficacy. Glucagon-like peptide 1 (GL......

Effect of lithium administration on brain activity under an emotion regulation paradigm in healthy participants: a functional magnetic resonance imaging study

期刊: PSYCHOPHARMACOLOGY, 2023; 240 (8)

RationaleEmotion regulation (ER) difficulties have been previously described in bipolar disorder (BD). Whilst lithium has been shown to be effective i......

The efficacy and tolerability of inhaled nitrous oxide in major depressive disorder: a systematic review and meta-analysis

期刊: PSYCHOPHARMACOLOGY, 2023; 240 (10)

BackgroundNitrous oxide (N2O) has been initially confirmed by clinical trials to benefit to patients with major depressive disorder (MDD). However, th......

Oral ketamine may offer a solution to the ketamine conundrum

期刊: PSYCHOPHARMACOLOGY, 2023; 240 (12)

Ketamine has received considerable attention for its rapid and robust antidepressant response over the past decade. Current evidence, in clinical popu......

Do oral contraceptives modulate the effects of stress induction on one-session exposure efficacy and generalization in women?

期刊: PSYCHOPHARMACOLOGY, 2023; 240 (5)

RationaleThe administration of glucocorticoids (GC) as an adjunct to exposure represents a promising strategy to improve one-session exposure outcome ......

Xanthohumol improves cognitive impairment by regulating miRNA-532-3p/Mpped1 in ovariectomized mice

期刊: PSYCHOPHARMACOLOGY, 2023; 240 (5)

RationaleStudies have shown the potential neuroprotective effect of xanthohumol, while whether xanthohumol has the ability of repairing cognitive impa......

Impaired extinction of operant cocaine in a genetic mouse model of schizophrenia risk

期刊: PSYCHOPHARMACOLOGY, 2023; 240 (7)

BackgroundIndividuals with schizophrenia have high rates of comorbid substance use problems. One potential explanation for this comorbidity is similar......

Neuroprotective effect of salidroside on hippocampal neurons in diabetic mice via PI3K/Akt/GSK-3β signaling pathway

期刊: PSYCHOPHARMACOLOGY, 2023; 240 (9)

Background Diabetic encephalopathy is manifested by cognitive dysfunction. Salidroside, a nature compound isolated from Rhodiola rosea L, has the effe......

Facial expressions of pain: the role of the serotonergic system

期刊: PSYCHOPHARMACOLOGY, 2023; 240 (12)

RationaleAlthough interest in the neurobiology of facial communication of pain has increased over the last decades, little is known about which neurot......

The M1 muscarinic acetylcholine receptor regulates the surface expression of the AMPA receptor subunit GluA2 via PICK1

期刊: PSYCHOPHARMACOLOGY, 2023; 240 (1)

Muscarinic acetylcholine receptors (mAChRs) have been shown to play significant roles in the regulation of normal cognitive processes in the hippocamp......

Probing the antidepressant potential of psilocybin: integrating insight from human research and animal models towards an understanding of neural circuit mechanisms

期刊: PSYCHOPHARMACOLOGY, 2023; 240 (1)

Interest in the therapeutic potential of serotonergic psychedelic compounds including psilocybin has surged in recent years. While human clinical rese......

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