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The activity of cytokines in dental pulp

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (9)

Background After binding to their corresponding receptors, cytokines mediate a variety of biological activities. However, the activity of cytokines in......

JIF:3.0

Characterization of the evolution trajectory and immune profiling of new histologic patterns in lung adenocarcinoma

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (11)

In lung adenocarcinoma (LUAD), the appearance of morphologically diverse tumor regions, termed histological patterns, is closely associated with disea......

JIF:3.0

CDK14/beta-catenin/TCF4/miR-26b positive feedback regulation modulating pancreatic cancer cell phenotypes in vitro and tumor growth in mice model in vivo

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (2)

Introduction: Chemotherapy and radiotherapy have been reported to be basically ineffective for pancreatic ductal adenocarcinoma patients; thus, gene t......

JIF:3.0

LINC01291 promotes hepatocellular carcinoma development by targeting the miR-186-5p/OXSR1 axis

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (2)

Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Recent studies have demonstrated that lncRNAs play an important......

JIF:3.0

Association between polymorphisms of ABCB1 and prognosis in esophageal squamous cell carcinoma patients treated with taxane

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (7)

Background In China, most esophageal cancer patients are squamous cell carcinomas and are treated with taxane-containing regimens; however, few studie......

JIF:3.0

Circular RNA ITCH attenuates the progression of nasopharyngeal carcinoma by inducing PTEN upregulation via miR-214

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (1)

Background Circular RNA itchy E3 ubiquitin protein ligase (circ-ITCH) has previously been reported to play a key role in carcinogenesis. Nevertheless,......

JIF:3.0

CSRP3, p.Arg122*, is responsible for hypertrophic cardiomyopathy in a Chinese family

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (1)

Background Hypertrophic cardiomyopathy (HCM) is a hereditary disease manifested by a thickened ventricular wall. Cysteine and glycine-rich protein 3 (......

JIF:3.0

EZH2 upregulates the expression of MAPK1 to promote intervertebral disc degeneration via suppression of miR-129-5p

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (3)

Background This study was designed to verify whether enhancer of zeste homolog 2 (EZH2) affects intervertebral disc degeneration (IVDD) development th......

JIF:3.0

ANKRD37 inhibits trophoblast migration and invasion by regulating the NF-kappa B pathway in preeclampsia

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (5)

Background: Inadequate trophoblast invasion is associated with preeclampsia (PE). Ankyrin repeat domain protein 37 (ANKRD37) has been reported to be a......

JIF:3.0

Potentially functional genetic variants of the notch signaling pathway genes predict survival of Chinese patients with esophageal squamous cell carcinoma

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (10)

Background The Notch signaling pathway is involved in the progression of esophageal squamous cell carcinoma (ESCC), although the roles of single nucle......

JIF:3.0

Extracellular vesicle-packaged miR-181c-5p from epithelial ovarian cancer cells promotes M2 polarization of tumor-associated macrophages via the KAT2B/HOXA10 axis

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (10)

Objectives The molecular mechanistic actions of tumor-derived extracellular vesicles (EVs) in modulating macrophage polarization in the tumor microenv......

JIF:3.0

Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF-beta 1/Smad3 signaling pathway

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (9)

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic and advanced interstitial lung disease with poor prognosis. AHNAK nucleoprotein 2 (AHNAK2......

JIF:3.0

Noninvasive detection of fetal genetic variations through polymorphic site sequencing of maternal plasma DNA

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (3)

Background Noninvasive prenatal testing (NIPT) for common fetal aneuploidies has been widely adopted in clinical practice for its sensitivity and accu......

JIF:3.0

SYNGR2 serves as a prognostic biomarker and correlates with immune infiltrates in esophageal squamous cell carcinoma

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (8)

Background Synaptogyrin-2 (SYNGR2) plays an important role in regulating membrane traffic in non-neuronal cells. However, the role of SYNGR2 in esopha......

JIF:3.0

Association study of miR-149, miR-196a2, and miR-499a polymorphisms with coronary artery aneurysm of Kawasaki disease in southern Chinese population

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (4)

Background Accumulating evidence suggests that several microRNA (miRNA) polymorphisms are closely associated with disease susceptibility or progressio......

JIF:3.0

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