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RVX-208, an inducer of Apolipoprotein A-I, inhibits the particle production of hepatitis B virus through activation of cGAS-STING pathway

期刊: ANTIVIRAL THERAPY, 2023; 28 (6)

BackgroundPreviously, we have demonstrated that Apolipoprotein A-I (ApoA-I) could inhibit the secretion of Hepatitis B virus (HBV), suggesting that st......

Genotypic and phenotypic characterization of influenza A viral variants in study participants treated with pimodivir in the phase 2b TOPAZ study

期刊: ANTIVIRAL THERAPY, 2023; 28 (3)

BackgroundPimodivir is a first-in-class polymerase basic protein 2 (PB2) subunit inhibitor of the influenza A polymerase complex. The randomized doubl......

Abacavir safety and effectiveness in young infants with HIV in South African observational cohorts

期刊: ANTIVIRAL THERAPY, 2023; 28 (2)

Background: WHO guidelines recommend abacavir in first-line antiretroviral treatment for children and neonates. However, there is no approved dose &lt......

Fanconi syndrome, diabetes insipidus, and acute kidney injury due to tenofovir disoproxil fumarate: A case report

期刊: ANTIVIRAL THERAPY, 2023; 28 (3)

BackgroundTenofovir disoproxil fumarate is widely used in Botswana as part of the first-line antiretroviral regimen in the 'Treat All' strategy implem......

HIV drug resistance in the era of contemporary antiretroviral therapy: A clinical perspective

期刊: ANTIVIRAL THERAPY, 2023; 28 (5)

Contemporary antiretroviral therapy (ART) regimens have high barriers to the development of drug resistance. However, resistance to earlier antiretrov......

Hepatitis C virus/Hepatitis B virus coinfection: Current prospectives

期刊: ANTIVIRAL THERAPY, 2023; 28 (4)

In endemic areas, hepatitis C virus (HCV)/hepatitis B virus (HBV) coinfection is common, and patients with coinfection have a higher risk of developin......

Case report and literature review: A hiccup patient developed encephalitis and duodenal perforation

期刊: ANTIVIRAL THERAPY, 2023; 28 (2)

Brainstem encephalitis is rare and this study aims to report the clinical course, imaging features, and therapeutic response of hiccup patient with ga......

Andrographolide inhibits infectious bronchitis virus-induced apoptosis, pyroptosis, and inflammation

期刊: ANTIVIRAL THERAPY, 2023; 28 (5)

Background: Avian infectious bronchitis virus (IBV), a coronavirus, causes a huge economic loss to the poultry industry. Andrographolide (APL) is a co......

A single, oral dose of the TLR7 agonist JNJ-64794964 induces transcriptomic and phenotypic changes in peripheral immune cells in healthy adults

期刊: ANTIVIRAL THERAPY, 2023; 28 (3)

BackgroundChronic hepatitis B (CHB) is responsible for major disease burden worldwide. However, the number of available therapies is limited; cure rem......

Feminizing hormone therapy in a Canadian cohort of transgender women with and without HIV

期刊: ANTIVIRAL THERAPY, 2023; 28 (3)

BackgroundPotential bidirectional drug-drug interactions between feminizing hormone therapy (FHT) and antiretroviral therapy (ART) are of concern for ......

The evolution of clinical study design in heavily treatment-experienced persons with HIV: A critical review

期刊: ANTIVIRAL THERAPY, 2023; 28 (3)

Heavily treatment-experienced (HTE) persons with HIV have limited options for antiretroviral therapy and face many challenges, complicating their dise......

Retrospective chart review of transplant recipients with cytomegalovirus infection who received maribavir in the Phase 3 SOLSTICE trial: Data at 52 weeks post-maribavir treatment initiation

期刊: ANTIVIRAL THERAPY, 2023; 28 (5)

Background: Cytomegalovirus (CMV) infection is a frequent complication in haematopoietic cell/solid organ transplant (HCT/SOT) recipients. Previous st......

Population pharmacokinetic/pharmacodynamic models of JNJ-64794964, a toll-like receptor 7 agonist, in healthy adult participants

期刊: ANTIVIRAL THERAPY, 2023; 28 (1)

BackgroundJNJ-4964 is a TLR7 agonist, which, via a type I interferon (IFN)-dependent mechanism, may enhance host immunity suppressed by persistent exp......

Treatment-related early discontinuations and adverse events among newly diagnosed people living with HIV initiating integrase inhibitors in a real-world setting

期刊: ANTIVIRAL THERAPY, 2023; 28 (2)

BackgroundCohort studies suggest higher discontinuation rates with integrase strand transfer inhibitors (INSTIs) than are seen in clinical trials. We ......

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