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Sentinel node mapping for post-endoscopic resection gastric cancer: multicenter retrospective cohort study in Japan

期刊: GASTRIC CANCER, 2020; 23 (4)

Background Standard gastrectomy with systematic lymphadenectomy as an additional surgery after endoscopic resection (ER) causes a deterioration in lon......

Construction of(124)I-trastuzumab for noninvasive PET imaging of HER2 expression: from patient-derived xenograft models to gastric cancer patients

期刊: GASTRIC CANCER, 2020; 23 (4)

Purpose Here, we sought to develop a PET radioligand based on trastuzumab labeled with(124)I,I-124-trastuzumab, to evaluate its distribution, internal......

Resistance to FGFR1-targeted therapy leads to autophagy via TAK1/AMPK activation in gastric cancer

期刊: GASTRIC CANCER, 2020; 23 (6)

Background Fibroblast growth factor receptor 1 (FGFR1) is frequently dysregulated in various tumors. FGFR inhibitors have shown promising therapeutic ......

Spectrum of activity of dasatinib against mutant KIT kinases associated with drug-sensitive and drug-resistant gastrointestinal stromal tumors

期刊: GASTRIC CANCER, 2020; 23 (5)

Background The majority of GISTs express mutationally activated KIT. Imatinib and sunitinib are approved KIT-inhibiting therapies. Their efficacy is u......

A deep learning method for delineating early gastric cancer resection margin under chromoendoscopy and white light endoscopy

期刊: GASTRIC CANCER, 2020; 23 (5)

Background Accurate delineation of cancer margins is critical for endoscopic curative resection. This study aimed to train and validate real-time full......

eIF4EBP3 was downregulated by methylation and acted as a tumor suppressor by targeting eIF4E/beta-catenin in gastric cancer

期刊: GASTRIC CANCER, 2020; 23 (3)

Background Epigenetic aberrations of tumor suppressor genes (TSGs), particularly DNA methylation, are frequently involved in the pathogenesis of gastr......

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