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Risk Factor Profiles Differ for Cancers of Different Regions of the Colorectum

期刊: GASTROENTEROLOGY, 2020; 159 (1)

BACKGROUND & AIMS: The molecular features of colorectal tumors differ with their anatomic location. Colorectal tumors are usually classified as pr......

Retinoic Acid and Lymphotoxin Signaling Promote Differentiation of Human Intestinal M Cells

期刊: GASTROENTEROLOGY, 2020; 159 (1)

BACKGROUND & AIMS: Intestinal microfold (M) cells are a unique subset of intestinal epithelial cells in the Peyer's patches that regulate mucosal ......

Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples From a Hong Kong Cohort: Systematic Review and Meta-analysis

期刊: GASTROENTEROLOGY, 2020; 159 (1)

BACKGROUND & AIMS: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which h......

ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice

期刊: GASTROENTEROLOGY, 2020; 159 (1)

BACKGROUND & AIMS: We investigated whether ABL protooncogene 1, non-receptor tyrosine kinase (ABL1) is involved in development of hepatocellular c......

Hepatocellular Carcinoma Cells Up-regulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-Cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice

期刊: GASTROENTEROLOGY, 2020; 159 (2)

BACKGROUND & AIMS: Immune checkpoint inhibitors are effective in the treatment of some hepatocellular carcinomas (HCCs), but these tumors do not a......

Corticosteroids, But Not TNF Antagonists, Are Associated With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results From an International Registry

期刊: GASTROENTEROLOGY, 2020; 159 (2)

BACKGROUND AND AIMS: The impact of Coronavirus disease 2019 (COVID-19) on patients with inflammatory bowel disease (IBD) is unknown. We sought to char......

Effects of Hepatitis B Surface Antigen on Virus-Specific and Global T Cells in Patients With Chronic Hepatitis B Virus infection

期刊: GASTROENTEROLOGY, 2020; 159 (2)

BACKGROUND & AIMS: Chronic hepatitis B virus (HBV) infection is characterized by the presence of defective viral envelope proteins (hepatitis B su......

The Protective Effects of Calcineurin on Pancreatitis in Mice Depend on the Cellular Source

期刊: GASTROENTEROLOGY, 2020; 159 (3)

BACKGROUND & AIMS: Calcineurin is a ubiquitously expressed central Ca2 thorn -responsive signaling molecule that mediates acute pancreatitis, but ......

Agonist of RORA Attenuates Nonalcoholic Fatty Liver Progression in Mice via Up-regulation of MicroRNA 122

期刊: GASTROENTEROLOGY, 2020; 159 (3)

BACKGROUND & AIMS: Development of nonalcoholic steatohepatitis (NASH) is associated with reductions in hepatic microRNA122 (MIR122); the RAR relat......

Aspirin Reduces Colorectal Tumor Development in Mice and Gut Microbes Reduce its Bioavailability and Chemopreventive Effects

期刊: GASTROENTEROLOGY, 2020; 159 (3)

BACKGROUND & AIMS: Alterations in the intestinal microbiota affect development of colorectal cancer and drug metabolism. We studied whether the in......

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