期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 153 (4)
Although microglia are associated with chronic pain, the role of spinal microglia in the regulation of itch remains unclear. In this study, we charact......
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 151 (2)
Caffeic acid has been indicated to benefit cholesterol balance, but the effect of pure caffeic acid on atherosclerosis in vivo has not been tested. Gi......
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 151 (4)
Histamine is a well-known inflammatory mediator, but how histamine induces angiogenesis remains poorly understood. In the present study, we demonstrat......
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 152 (1)
Purpose: Oral administration of 5-aminolevulinic acid hydrochloride (5-ALA-HCl) has been reported to enhance the hypotensive effects associated with a......
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 152 (2)
We investigated the extracellular Ca2+ influx pathways involved in platelet-activating factor (PAF)enhanced guinea pig detrusor smooth muscle (DSM) co......
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 153 (3)
Transporter-mediated clearance is determined by two factors, its single-molecule clearance, and expression level. However, no reliable method has been......
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 151 (2)
Mirtazapine, an atypical antidepressant, is known to enhance serotonergic transmission by inhibiting the 5-hydroxytryptamine (5-HT)1A, 5-HT2C, and 5-H......
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 151 (2)
Pulmonary arterial hypertension (PAH) is a progressive and fatal disease that is characterized by vascular remodeling of the pulmonary artery. PAH rem......
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 153 (3)
Increasing evidence indicates that immune abnormalities are associated with the pathogenesis of depression. CCR4 is a chemokine receptor that regulate......
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 151 (1)
Atherosclerotic plaques develop from the accumulation of macrophage-derived foam cells via the uptake of modified low-density lipoprotein (LDL). CD36 ......
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 153 (3)
The usefulness of NUDT15 genotyping as a pharmacogenomic test for thiopurine has been established. The first such test developed to date, NUDT15 genot......
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 151 (1)
Triamcinolone acetonide (TA) has been shown to improve morphological and functional outcome in diabetic macular edema (DME) patients. However, the fun......
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 153 (1)
SET and MYND domain protein 2 (SMYD2) can methylate histone H3 at lysine36 (H3K36) and some non -histone substrates to play a role in tumorigenesis. H......
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 151 (4)
Allyl isothiocyanate (AITC) activates transient receptor potential ankyrin 1 (TRPA1) channel, which is involved in the control of intestinal mucosal b......
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES, 2023; 152 (1)
Fatigue is a serious health problem, and long-term fatigue can lead to mental illnesses and accelerated aging. Oxidative stress, which causes excessiv......