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Incorporating a greater diversity of cell types, including microglia, in brain organoid cultures improves clinical translation

期刊: JOURNAL OF NEUROCHEMISTRY, 2023; 164 (5)

Brain organoids have the potential to improve clinical translation, with the added benefit of reducing any extraneous use of experimental animals. As ......

Ceruloplasmin-deficient mice show changes in PTM profiles of proteins involved in messenger RNA processing and neuronal projections and synaptic processes

期刊: JOURNAL OF NEUROCHEMISTRY, 2023; 165 (1)

Ceruloplasmin (Cp) is a multicopper oxidase with ferroxidase properties being of importance to the mobilisation and export of iron from cells and its ......

Innovations advancing our understanding of microglia in Alzheimer's disease: From in vitro to in vivo models

期刊: JOURNAL OF NEUROCHEMISTRY, 2023; 166 (3)

Microglia have been implicated in Alzheimer's disease (AD) pathogenesis through the identification of risk factor genes that are specifically or predo......

Phase separation of the mammalian prion protein: Physiological and pathological perspectives

期刊: JOURNAL OF NEUROCHEMISTRY, 2023; 166 (1)

Abnormal phase transitions have been implicated in the occurrence of proteinopathies. Disordered proteins with nucleic acidbinding ability drive the f......

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