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More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy

期刊: ACTA NEUROPATHOLOGICA, 2023; 146 (3)

The accumulation of proteinaceous inclusions in the brain is a common feature among neurodegenerative diseases such as Alzheimer's disease, Parkinson'......

Widespread CNS pathology in amyotrophic lateral sclerosis homozygous for the D90A SOD1 mutation

期刊: ACTA NEUROPATHOLOGICA, 2023; 145 (1)

Mutations in the gene encoding the ubiquitously expressed free radical scavenging enzyme superoxide dismutase-1 (SOD1) are found in 2-6% of amyotrophi......

Microglia activation in periplaque white matter in multiple sclerosis depends on age and lesion type, but does not correlate with oligodendroglial loss

期刊: ACTA NEUROPATHOLOGICA, 2023; 146 (6)

Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of the CNS. The disease course in MS is highly variable and driven......

Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts

期刊: ACTA NEUROPATHOLOGICA, 2023; 145 (1)

Molecular groups of medulloblastoma (MB) are well established. Novel risk stratification parameters include Group 3/4 (non-WNT/non-SHH) methylation su......

Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification

期刊: ACTA NEUROPATHOLOGICA, 2023; 145 (5)

Group 4 tumours (MBGrp4) represent the majority of non-WNT/non-SHH medulloblastomas. Their clinical course is poorly predicted by current risk-factors......

Central and peripheral myeloid-derived suppressor cell-like cells are closely related to the clinical severity of multiple sclerosis

期刊: ACTA NEUROPATHOLOGICA, 2023; 146 (2)

Multiple sclerosis (MS) is a highly heterogeneous demyelinating disease of the central nervous system (CNS) that needs for reliable biomarkers to fore......

Transcriptomic profiling of Parkinson's disease brains reveals disease stage specific gene expression changes

期刊: ACTA NEUROPATHOLOGICA, 2023; 146 (2)

Parkinson & PRIME;s disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Aggravation of sy......

Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons

期刊: ACTA NEUROPATHOLOGICA, 2023; 145 (2)

The major neuropathological hallmarks of Alzheimer's disease (AD) are amyloid beta (A beta) plaques and neurofibrillary tangles (NFT), accompanied by ......

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