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Antifungal therapy: Novel drug delivery strategies driven by new targets

期刊: ADVANCED DRUG DELIVERY REVIEWS, 2023; 199 ()

In patients with compromised immunity, invasive fungal infections represent a significant cause of mor-tality. Given the limited availability and draw......

Transdermal drug delivery via microneedles to mediate wound microenvironment

期刊: ADVANCED DRUG DELIVERY REVIEWS, 2023; 195 ()

Cutaneous wound healing is a complex process, while modulating the wound microenvironment has become an essential therapeutic goal. In clinics, advanc......

From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer

期刊: ADVANCED DRUG DELIVERY REVIEWS, 2023; 196 ()

Brain cancer remains the deadliest cancer. The blood-brain barrier (BBB) is impenetrable to most drugs and is a complex 3D network of multiple cell ty......

Impact of the host microbiota on fungal infections: New possibilities for intervention?

期刊: ADVANCED DRUG DELIVERY REVIEWS, 2023; 198 ()

Many human fungal pathogens are opportunistic. They are primarily benign residents of the human body and only become infectious when the host's immuni......

Nanomaterial-based ophthalmic drug delivery

期刊: ADVANCED DRUG DELIVERY REVIEWS, 2023; 200 ()

The low bioavailability and side effects of conventional drugs for eye disease necessitate the development of efficient drug delivery systems. Accompa......

Peptide-containing nanoformulations: Skin barrier penetration and activity contribution

期刊: ADVANCED DRUG DELIVERY REVIEWS, 2023; 203 ()

Transdermal drug delivery presents a less invasive pathway, circumventing the need to pass through the gastrointestinal tract and liver, thereby reduc......

Overcoming biological barriers by virus-like drug particles for drug delivery

期刊: ADVANCED DRUG DELIVERY REVIEWS, 2023; 203 ()

Virus-like particles (VLPs) have natural structural antigens similar to those found in viruses, making them valuable in vaccine immunization. Furtherm......

A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics

期刊: ADVANCED DRUG DELIVERY REVIEWS, 2023; 201 ()

Small interfering RNAs (siRNAs) are among the most promising therapeutic platforms in many life-threatening diseases. Owing to the significant advance......

Injectable systems for long-lasting insulin therapy

期刊: ADVANCED DRUG DELIVERY REVIEWS, 2023; 203 ()

Insulin therapy is the mainstay to treat diabetes characterizedd by hyperglycemia. However, its short half-life of only 4-6 min limits its effectivene......

Engineering cells for precision drug delivery: New advances, clinical translation, and emerging strategies

期刊: ADVANCED DRUG DELIVERY REVIEWS, 2023; 197 ()

Cells have emerged as a promising new form of drug delivery carriers owing to their distinguished advan-tages such as naturally bypassing immune recog......

Emerging drug delivery systems with traditional routes - A roadmap to chronic inflammatory diseases

期刊: ADVANCED DRUG DELIVERY REVIEWS, 2023; 203 ()

Inflammation is prevalent and inevitable in daily life but can generally be accommodated by the immune systems. However, incapable self-healing and pe......

Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment

期刊: ADVANCED DRUG DELIVERY REVIEWS, 2023; 194 ()

Atherosclerosis, a chronic cardiovascular disease caused by plaque development in arteries, remains a leading cause of morbidity and mortality. Athero......

Nano-based eye drop: Topical and noninvasive therapy for ocular diseases

期刊: ADVANCED DRUG DELIVERY REVIEWS, 2023; 194 ()

Eye drops are the most accessible therapy for ocular diseases, while inevitably suffering from their lower bioavailability which highly restricts the ......

Microbiota and plant-derived vesicles that serve as therapeutic agents and delivery carriers to regulate metabolic syndrome

期刊: ADVANCED DRUG DELIVERY REVIEWS, 2023; 196 ()

The gut is a fundamental organ in controlling human health. Recently, researches showed that substances in the intestine can alter the course of many ......

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