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Blood coagulation factors and platelet response to drug-induced hepatitis and hepatosis in rats

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; 6 (1)

BackgroundKnowing the variability of blood coagulation responses to liver damage of different origins can provide a key to curing liver tissues or to ......

Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model, cellular platform, and clinical human data

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; 6 (6)

Head and neck squamous cell cancer (HNSCC) is a leading global malignancy. Every year, More than 830 000 people are diagnosed with HNSCC globally, wit......

Humanization for neurological disease modeling: A roadmap to increase the potential of Drosophila model systems

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; 6 (3)

Neuroscience and neurology research is dominated by experimentation with rodents. Around 75% of neurology disease-associated genes have orthologs in D......

Simple procedure for assessing diffuse subarachnoid hemorrhage successfully created using filament perforation method in mice

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; ()

The murine model of subarachnoid hemorrhage (SAH) is a valuable experimental tool for investigating molecular and cellular mechanisms, and the endovas......

Comparison of sublingual microcirculatory parameters measured by sidestream darkfield videomicroscopy in anesthetized pigs and adult humans

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; 6 (5)

BackgroundThis study aimed to compare sublingual microcirculatory parameters between anesthetized pigs and conscious adult humans using sidestream dar......

Histological and magnetic resonance imaging assessment of Liqoseal in a spinal in vivo pig model

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; 6 (1)

BackgroundLiqoseal (Polyganics, B.V.) is a dural sealant patch for preventing postoperative cerebrospinal fluid (CSF) leakage. It has been extensively......

A study of the influence of genetic variance and sex on the density and thickness of the calvarial bone in collaborative cross mice

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; 6 (4)

BackgroundBone microarchitecture is affected by multiple genes, each having a small effect on the external appearance. It is thus challenging to chara......

Lowering fasting blood glucose with non-dialyzable material of cranberry extract is dependent on host genetic background, sex and diet

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; 6 (3)

BackgroundType 2 diabetes (T2D) is a polygenic metabolic disease, characterized by high fasting blood glucose (FBG). The ability of cranberry (CRN) fr......

Plethysmograph training: A refinement for collection of respiration data in mice

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; 6 (4)

Inhaled chemicals can harm the airways. Different effects can result in distinct changes in respiratory patterns; the type of change indicates where a......

Use of a rat model to characterize 35 arterial pulse wave parameters in a comparative study of isoflurane and Zoletil/xylazine anesthesia and the effect of Acanthopanax senticosus extract

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; 6 (5)

Background Information obtained from arterial pulse waveforms (APW) can be useful for characterizing the cardiovascular system. To achieve this, it is......

Validation of a surgical model for posthepatectomy liver failure in rats

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; 6 (3)

BackgroundThe upper limit for liver resections in rats is approximately 90%. In the early postoperative phase, mortality increases. The aim of the pre......

Blindmen and an elephant: The need for animals in research, drug safety studies, and understanding civilizational diseases

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; 6 (6)

Animal-based research and drug safety studies are essential to understanding the mysteries of nature and the long-term survival of humans. Due to the ......

High-fat diet and oral infection induced type 2 diabetes and obesity development under different genetic backgrounds

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; 6 (2)

BackgroundType 2 diabetes (T2D) is an adult-onset and obese form of diabetes caused by an interplay between genetic, epigenetic, and environmental com......

Poke And Delayed Drink Intertemporal Choice Task (POKE-ADDICT): An open-source behavioral apparatus for intertemporal choice testing in rodents

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; 6 (6)

Advancements in neuroscience research present opportunities and challenges, requiring substantial resources and funding. To address this, we describe ......

Zataria multiflora and its constituent, carvacrol, counteract sepsis-induced aortic and cardiac toxicity in rat: Involvement of nitric oxide and oxidative stress

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2023; 6 (3)

BackgroundZataria multiflora and carvacrol showed various pharmacological properties including anti-inflammatory and anti-oxidant effects. However, up......

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