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Cross-talk between AMP-activated protein kinase and the sonic hedgehog pathway in the high-fat diet triggered colorectal cancer

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 735 ()

The major cause of colorectal cancer (CRC) related mortality is due to its metastasis. Signaling pathways play a definite role in the development and ......

Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 736 ()

Nabumetone, a nonsteroidal anti-inflammatory prodrug, is converted to a pharmacologically active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA); ......

Enzymatic activation in vitamin D signaling-Past, present and future

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 742 ()

Vitamin D signaling is important in regulating calcium homeostasis essential for bone health but also displays other functions in cells of several tis......

Transcriptome profile analysis reveals putative molecular mechanisms of 5-aminolevulinic acid toxicity

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 738 ()

5-aminolevulinic acid (5-ALA) is the first precursor of the heme biosynthesis pathway, accumulated in acute intermittent porphyria (AIP), an inherited......

β-Carotene induces UCP1-independent thermogenesis via ATP-consuming futile cycles in 3T3-L1 white adipocytes

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 739 ()

The activation of brown fat and induction of beige adipocytes, so-called non-shivering thermogenesis, is emerging as a promising target for therapeuti......

CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 745 ()

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide. Cytochrome P450 2E1 (CYP2E1) is an enzyme, primarily involved i......

Mechanistic and thermodynamic characterization of antiviral inhibitors targeting nucleocapsid N-terminal domain of SARS-CoV-2

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 750 ()

The nucleocapsid (N) protein of SARS-CoV-2 plays a pivotal role in encapsulating the viral genome. Developing antiviral treatments for SARS-CoV-2 is i......

N-butyrate increases heat shock protein 70 through heat shock factor 1 and AMP-activated protein kinase pathways in human intestinal Caco-2 cells

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 736 ()

Impaired integrity of the intestinal epithelium is a cause of intestinal and extraintestinal diseases. Heat shock protein 70 (HSP70), a cytoprotective......

Diosgenin prevents dexamethasone-induced myotube atrophy in C2C12 cells

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 747 ()

Several pathophysiological abnormalities, including a sedentary lifestyle, chronic diseases, and oxidative stress, can contribute to muscle atrophy tr......

CNT-FET for sensitive hydrogen peroxide biosensing via immobilized Cytochrome c

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 744 ()

H2O2 is an effective substance in the body which contributes to gene expression, insulin metabolism and determining cell shapes. However, a high conce......

Biochemical interactions between the Atm1-like transporter from Novosphingobium aromaticivorans and heavy metals

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 744 ()

Novosphingobium aromaticivorans has the ability to survive in harsh environments by virtue of its suite of ironcontaining oxygenases that biodegrade a......

New iron export pathways acting via holo-ferritin secretion

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 746 ()

Ferritin is a spherical nanocage protein for iron storage, composed of 24 light- or heavy-polypeptide chain subunits. A single ferritin molecule can c......

Protective effect of exogenous peroxiredoxin 6 and thymic peptide thymulin on BBB conditions in an experimental model of multiple sclerosis

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 746 ()

This study aimed to assess the effects of the immunomodulator thymulin, a thymic peptide with antiinflammatory effects, and peroxiredoxin 6 (Prdx6), a......

Effect of lipid oxidation on the channel properties of Cx26 hemichannels: A molecular dynamics study

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 746 ()

Intercellular communication plays a crucial role in cancer, as well as other diseases, such as inflammation, tissue degeneration, and neurological dis......

Enzymes in riboflavin biosynthesis: Potential antibiotic drug targets

期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2023; 748 ()

The rapid resistance of pathogens to antibiotics has emerged as a major threat to global health. Identification of new antibiotic targets is thus need......

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