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Proteomic aptamer analysis reveals serum markers that characterize preclinical systemic sclerosis (SSc) patients at risk for progression toward definite SSc

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

BackgroundThe study of molecular mechanisms characterizing disease progression may be relevant to get insights into systemic sclerosis (SSc) pathogene......

Machine learning identification of thresholds to discriminate osteoarthritis and rheumatoid arthritis synovial inflammation

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

BackgroundWe sought to identify features that distinguish osteoarthritis (OA) and rheumatoid arthritis (RA) hematoxylin and eosin (H&E)-stained sy......

Equine osteoarthritis modifies fatty acid signatures in synovial fluid and its extracellular vesicles

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

BackgroundIndividual fatty acids (FAs) and their derivatives (lipid mediators) with pro-inflammatory or dual anti-inflammatory and pro-resolving prope......

Optical spectral transmission to assess glucocorticoid therapy response in patients with arthritis: a longitudinal follow-up comparison with joint ultrasound

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

BackgroundOptical spectral transmission (OST) is a modern diagnostic modality, able to assess the blood-specific absorption of light transmitted throu......

Dopamine D2 receptor on CD4+ T cells is protective against inflammatory responses and signs in a mouse model of rheumatoid arthritis

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

BackgroundDopamine is a neurotransmitter and has been found to regulate lymphocytes by acting on dopamine receptors (DRs). CD4(+) T cells express all ......

B cell subsets in adult-onset Still's disease: potential candidates for disease pathogenesis and immunophenotyping

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

BackgroundAdult-onset Still's disease (AOSD) is a systemic autoinflammatory disorder of unknown etiology. B cells are critical participants in differe......

Left ventricular remodeling in rheumatoid arthritis patients without clinical heart failure

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

Rheumatoid arthritis (RA) patients have a 1.5- to twofold higher risk of developing heart failure (HF) and a twofold increased risk of HF-associated m......

Interleukin-1β inhibitors for the management of acute gout flares: a systematic literature review

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

Objectives The objective of this systematic review was to assess the effects of interleukin-1 beta (IL-1 beta) inhibitors on gout flares. Methods Stud......

Patients with radiographic axial spondylarthritis have an impaired dietary intake-a cross-sectional study with matched controls from northern Sweden

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

BackgroundRadiographic axial spondyloarthritis (r-axSpA) is one of the most common chronic inflammatory rheumatic diseases, affecting about 0.2% of th......

Causal associations of Sjogren′s syndrome with cancers: a two-sample Mendelian randomization study

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

Background Several observational studies have explored the associations between Sjogren ' s syndrome (SS) and certain cancers. Nevertheless, the causa......

Association of knee and hip osteoarthritis with the risk of falls and fractures: a systematic review and meta-analysis

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

Objective Studies evaluating the association of knee and hip osteoarthritis (OA) with falls and fractures have inconsistent findings. We aimed to inve......

Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB-GRB2/ERK/RUNX2 pathway

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

ObjectivesAnkylosing spondylitis (AS) is a chronic inflammatory disease that mainly affects the sacroiliac joint and spine. However, the real mechanis......

Interleukin-37: associations of plasma levels and genetic variants in gout

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

ObjectivesIL-37 is an anti-inflammatory cytokine involved in inflammatory and autoimmune diseases. We aimed to investigate the association between IL-......

CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

BackgroundCircular RNAs are involved in autoimmune disease pathogenesis. Our previous study indicated that circPTPN22 is involved in autoimmune diseas......

ACSL4 inhibition prevents macrophage ferroptosis and alleviates fibrosis in bleomycin-induced systemic sclerosis model

期刊： ARTHRITIS RESEARCH & THERAPY, 2023; 25 (1)

BackgroundSystemic sclerosis (SSc), with unclear pathophysiology, is a paradigmatic rheumatic disease of immunity dysfunction-driven multi-organ infla......

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