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Oral Gastroretentive Film of Lacidipine for the Treatment of Gastroparesis

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; 21 (3)

The research work was aimed to formulate and evaluate gastroretentive mucoadhesive film of calcium channel blocker, Lacidipine for treatment of gastro......

Adjusting the Fitting of Fluorescence-Based Dose-Response Kinase Inhibition Assay to Account for Fluorescent Inhibitors

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; 21 (7)

Fluorescence is routinely used to monitor kinase inhibition in commercial assays. Occasionally fluorescent compounds can interfere with the fluorescen......

Preparation and Optimization of Liposome Containing Thermosensitive In Situ Nasal Hydrogel System for Brain Delivery of Sumatriptan Succinate

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; 21 (1)

Drug absorption is improved by the intranasal route's wide surface area and avoidance of first-pass metabolism. For the treatment of central nervous s......

High-Throughput Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry Method Validation for the Estimation of Atorvastatin and Active Metabolites in Human Plasma

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; 21 (3)

A highly selective, sensitive, rugged, and rapid ultra high-performance liquid chromatography-tandem mass spectrometry method (UPLC-MS/MS) is optimize......

α-Tocopherol Polyethylene Glycol 1000 Succinate-Based Cationic Liposome for the Intracellular Delivery of Doxorubicin in MDA-MB-231 Triple-Negative Breast Cancer Cell Line

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; 21 (8)

Present research work reports the development of doxorubicin (DOX) loaded alpha-tocopherol polyethylene glycol 1000 succinate (TPGS)-coated cationic l......

A Short Appraisal of Biomimetic Hydrogels to Improve Penetration of Poorly Permeable Drugs

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; 21 (8)

Effective drug delivery to target sites is critical for achieving desired therapeutic outcomes. However, the poor permeability of certain drugs poses ......

Biosensor Assays Types and Their Roles Toward Ligand-Receptor Interactions in Drug Discovery

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; 21 (5)

Ligand-receptor interactions (LRIs) are the basis for all the biological processes taking place in living cells and have been exploited to develop and......

Formulation and Characterization of Nanoparticulate Drug Carrier System for Lacidipine

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; 21 (7)

Lacidipine, a calcium channel antagonist, is primarily used to treat hypertension. It is classified as a Biopharmaceutics Classification System Class ......

A Critical Sojourn of Polymeric Micelles: Technological Concepts, Recent Advances, and Future Prospects

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; 21 (2)

Poorly soluble drug molecules/phytoconstituents are still a growing concern for biopharmaceutical delivery in the body. Polymeric micelles are the amp......

Validation of a Novel Supercritical Fluid Extractor/Dryer Combo Instrument

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; 21 (3)

The current pharmaceutical manufacturing scenario involves different techniques for the processing of materials. For example, the extraction unit is o......

Development and Validation of Reverse-Phase High-Performance Liquid Chromatography Method for Simultaneous Estimation of Doxorubicin and Clotrimazole

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; ()

A reverse-phase high-performance liquid chromatographic (RP-HPLC) method was developed to analyze the simultaneous estimation of doxorubicin and clotr......

In-Silico Design, Synthesis, and Pharmacological Evaluation of Oxadiazole-Based Selective Cyclo-oxygenase-2 Inhibitors

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; 21 (4)

A series of oxadiazole-based five-membered heterocyclic derivatives was designed and synthesized with the intent of exclusive cyclo-oxygenase-2 (COX-2......

Quality by Design Approach for Optimization of Microbial and pH-Triggered Colon-Targeted Tablet Formulation Using Carboxymethyl Tamarind Gum

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; 21 (7)

The purpose of this study was to apply the quality by design (QbD) approach in the development of a microbial and pH-triggered colon-targeted budesoni......

Losartan Plays a Fungistatic and Fungicidal Activity Against Candida albicans Biofilms: Drug Repurposing for Localized Candidosis

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; 21 (4)

Candidosis is one of the most frequent opportunistic infections and exhibits variable clinical presentations, including oral localized forms. Drugs af......

Doxorubicin Conjugates: An Efficient Approach for Enhanced Therapeutic Efficacy with Reduced Side Effects

期刊: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2023; 21 (4)

Continuous drug delivery modification is the scientific approach and is a basic need for the efficient therapeutic efficacy of active drug molecules. ......

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