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Key Challenges and Recommendations for In Vitro Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters

期刊: ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2023; 51 (1)

The Institute for In Vitro Sciences (IIVS) is sponsoring a series of workshops to identify, discuss and develop recommendations for optimal scientific......

Is UK Animal Research Governance Facing a 'New Normal'? Considering the Risks and Benefits of 'Going Online'

期刊: ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2023; 51 (4)

Since a return to in-office working after the extensive disruption caused by the COVID-19 pandemic and associated challenges, many conversations are s......

Evaluating the Impact of Hair Care Product Exposure on Hair Follicle and Scalp Health

期刊: ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2023; 51 (5)

Human hair follicles traverse the epidermis and dermis, and are comprised of specialised cells including dermal papilla cells (DPCs). DPCs play a crit......

In Silico Prediction of Eye Irritation Using Hansen Solubility Parameters and Predicted pKa Values

期刊: ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2023; 51 (3)

An in silico method has been developed that permits the binary differentiation between pure liquids causing serious eye damage or eye irritation, and ......

The Use of In Silico Methods to Identify and Assess Antigenic Regions Suitable for the Development of Peptide-based Pan-viral Vaccines

期刊: ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2023; 51 (5)

The constant evolution of pathogenic viral variants and the emergence of new viruses have reinforced the need for broad-spectrum vaccines to combat su......

Poor Translatability of Biomedical Research Using Animals - A Narrative Review

期刊: ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2023; 51 (2)

The failure rate for the translation of drugs from animal testing to human treatments remains at over 92%, where it has been for the past few decades.......

The Application of New Approach Methodologies in Respiratory Disease Research: Their Role in Improving Translational Medicine from Bench to Bedside

期刊: ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2023; 51 (3)

The SARS-CoV-2 outbreak focused global attention on the shortcomings of the drug discovery process. It led to its acceleration in several areas, parti......

The 3Ranker: An AI-based Algorithm for Finding Non-animal Alternative Methods

期刊: ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2023; 51 (6)

The search for existing non-animal alternative methods for use in experiments is currently challenging because of the lack of both comprehensive struc......

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