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Why does the herpes simplex 1 virus-encoded UL49.5 protein fail to inhibit the TAP-dependent antigen presentation?

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2023; 1865 (8)

Herpes simplex virus 1 (HSV-1) is a well-studied herpesvirus that causes various human diseases. Like other herpesviruses, HSV-1 produces the transmem......

Cell-free synthesis and reconstitution of Bax in nanodiscs: Comparison between wild-type Bax and a constitutively active mutant

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2023; 1865 (1)

Bax is a major player in the mitochondrial pathway of apoptosis, by making the Outer Mitochondrial Membrane (OMM) permeable to various apoptogenic fac......

Bio-membranes: Picosecond to second dynamics and plasticity as deciphered by solid state NMR

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2023; 1865 (2)

Since the first membrane models in the 1970s, the concept of biological membranes has evolved considerably. The membrane is now seen as a very complex......

Specific Xray diffraction patterns of membrane proteins caused by secondary structure collinearity

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2023; 1865 (1)

Diffraction anisotropy is a phenomenon that impacts more specifically membrane proteins, compared to soluble ones, but the reasons for this discrepanc......

Optimization of detergents in solubilization and reconstitution of Aquaporin Z: A structural approach

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2023; 1865 (3)

Background: The exceptional capacities of aquaporins in terms of water permeation and selectivity have made them an interesting system for membrane ap......

A gating mechanism of the BsYetJ calcium channel revealed in an endoplasmic reticulum lipid environment

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2023; 1865 (5)

The transmembrane BAX inhibitor-1-containing motif 6 (TMBIM6) is suggested to modulate apoptosis by regulating calcium homeostasis in the endoplasmic ......

Efficiency of mitochondrial uncoupling by modified butyltriphenylphosphonium cations and fatty acids correlates with lipophilicity of cations: Protonophoric vs leakage mechanisms

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2023; 1865 (7)

In order to determine the share of protonophoric activity in the uncoupling action of lipophilic cations a number of analogues of butyltriphenylphosph......

Ts17, a Tityus serrulatus 8-toxin structurally related to α-scorpion toxins

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2023; 1865 (1)

Ts17 was purified from the venom of the scorpion Tityus serrulatus, the most dangerous scorpion species in Brazil. The activity on Nav1.1-Nav1.7 chann......

Refinement of Singer-Nicolson fluid-mosaic model by microscopy imaging: Lipid rafts and actin-induced membrane compartmentalization

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2023; 1865 (2)

This year celebrates the 50th anniversary of the Singer-Nicolson fluid mosaic model for biological membranes. The next level of sophistication we have......

Identification of membrane engineering targets for increased butanol tolerance in Clostridium saccharoperbutylacetonicum

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2023; 1865 (8)

There is a growing interest in the use of microbial cell factories to produce butanol, an industrial solvent and platform chemical. Biobutanol can als......

Antimicrobial peptide magainin 2-induced rupture of single giant unilamellar vesicles comprising E. coli polar lipids

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2023; 1865 (3)

Most antimicrobial peptides (AMPs) damage the cell membrane of bacterial cells and induce rapid leakage of the internal cell contents, which is a main......

Evidence for a transition in the cortical membranes of Paramecium

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2023; 1865 (1)

Ever since the pioneering studies in the 1960s and 70s, the importance of order transitions for cell membrane functions has remained a matter of debat......

The excitable fluid mosaic

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2023; 1865 (3)

The Fluid Mosaic Model by Singer & Nicolson proposes that biological membranes consist of a fluid lipid layer into which integral proteins are emb......

Development of a novel fluorescence assay for studying lipid bilayer perturbation induced by amyloidogenic peptides using cell plasma membrane vesicles

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2023; 1865 (3)

Numerous pathophysiological conditions are associated with the misfolding and aggregation of proteins into insoluble amyloid fibrils. The mechanisms b......

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