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Thermodynamic modulation of folding and aggregation energy landscape by DNA binding of functional domains of TDP-43

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (4)

TDP-43 is a vital nucleic acid binding protein which forms stress-induced aberrant aggregates in around 97% cases of ALS, a fatal neurodegenerative di......

Effect of flavonoids on the destabilization of a-synuclein fibrils and their conversion to amorphous aggregate: A molecular dynamics simulation and experimental study

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (6)

The second most prevalent neurodegenerative disease, Parkinson's disease (PD), is caused by the accumulation and deposition of fibrillar aggregates of......

The molecular basis of the antidepressant action of the magic mushroom extract, psilocin

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (4)

Magic mushrooms, and their extract psilocybin, are well-known for their psychedelic properties and recreational use. Psilocin, the bio-active form of ......

Reactive architecture profiling with a methyl acyl phosphate electrophile

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (6)

Activity-based protein profiling has facilitated the study of the activity of enzymes in proteomes, inhibitor development, and identification of enzym......

The anti-platelet drug ticlopidine inhibits FapC fibrillation and biofilm production: Highlighting its antibiotic activity

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (2)

Multidrug resistance of bacteria and persistent infections related to biofilms, as well as the low availability of new antibacterial drugs, make it ur......

Distinct dynamical features of plasmodial and human HSP70-HSP110 highlight the divergence in their chaperone-assisted protein folding

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (6)

HSP70 and its evolutionarily diverged co-chaperone HSP110, forms an important node in protein folding cascade. How these proteins maintain the aggrega......

Heterotypic liquid-liquid phase separation of tau and a-synuclein: Implications for overlapping neuropathologies

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (6)

Tauopathies and synucleinopathies are characterized by the aggregation of Tau and & alpha;-synuclein (AS) into amyloid structures, respectively. I......

The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (2)

Plakophilin 1 (PKP1), a member of the armadillo repeat family of proteins, is a key structural component of cellcell adhesion scaffolds, although it c......

The effect of pH and nitrite on the haem pocket of GLB-33, a globin-coupled neuronal transmembrane receptor of Caenorhabditis elegans

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (4)

Out of the 34 globins in Caenorhabditis elegans, GLB-33 is a putative globin-coupled transmembrane receptor with a yet unknown function. The globin do......

Comparison of force fields to study the zinc-finger containing protein NPL4, a target for disulfiram in cancer therapy

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (4)

Molecular dynamics (MD) simulations are a powerful approach to studying the structure and dynamics of proteins related to health and disease. Advances......

Kinetic control in amyloid polymorphism: Different agitation and solution conditions promote distinct amyloid polymorphs of alpha-synuclein

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (4)

Aggregation of neuronal protein & alpha;-synuclein is implicated in synucleinopathies, including Parkinson's disease. Despite abundant in vitro st......

Oligomeric state of the N-terminal domain of DnaT for replication restart in Escherichia coli

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (5)

DNA replication stops when chemical or physical damage occurs to the DNA. Repairing genomic DNA and reloading the replication helicase are crucial ste......

Modulation of α-synuclein phase separation by biomolecules

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (2)

Liquid-liquid phase separation (LLPS) is currently recognized as a common mechanism involved in the regulation of a number of cellular functions. On t......

Cd-induced cytosolic proteome changes in the cyanobacterium Anabaena sp. PCC7120 are mediated by LexA as one of the regulatory proteins

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (3)

LexA, a well-characterized transcriptional repressor of SOS genes in heterotrophic bacteria, has been shown to regulate diverse genes in cyanobacteria......

Understanding the mechanism of amylin aggregation: From identifying crucial segments to tracing dominant sequential events to modeling potential aggregation suppressors

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2023; 1871 (1)

One of the most abundant, prevailing, and life-threatening human diseases that are currently baffling the scientific community is type 2 diabetes (T2D......

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