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Proteins and their functionalization for finding therapeutic avenues in cancer: Current status and future prospective

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (2)

Despite the remarkable advancement in the health care sector, cancer remains the second most fatal disease globally. The existing conventional cancer ......

USP7-a crucial regulator of cancer hallmarks

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (3)

Over the course of three decades of study, the deubiquitinase Herpesvirus associated Ubiquitin-Specific Protease/ Ubiquitin-Specific Protease 7 (HAUSP......

S-Nitrosylation at the intersection of metabolism and autophagy: Implications for cancer

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (6)

Metabolic plasticity, which determines tumour growth and metastasis, is now understood to be a flexible and context-specific process in cancer metabol......

The role of truncated p53 isoforms in the DNA damage response

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (3)

The tumour suppressor p53 is activated following genotoxic stress and regulates the expression of target genes involved in the DNA damage response (DD......

Long non-coding RNAs: Fundamental regulators and emerging targets of cancer stem cells

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (3)

Cancer is one of the leading causes of death worldwide, primarily due to the dearth of efficient therapies that result in long-lasting remission. This......

GDF11 as a friend or an enemy in the cancer biology?

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (5)

The Growth and Differential Factor 11 (GDF11) is a recently discovered representative of Transforming Growth Factor ss superfamily. The highest expres......

Glioma and post-translational modifications: A complex relationship

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (6)

Post-translational modifications (PTMs) are common covalent processes in biochemical pathways that alter protein function and activity. These modifica......

The Warburg effect on radioresistance: Survival beyond growth

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (6)

The Warburg effect is a phenomenon in which cancer cells rely primarily on glycolysis rather than oxidative phosphorylation, even in the presence of o......

An update on Merkel cell carcinoma

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (3)

Merkel cell carcinoma (MCC) is a rare cancer of the skin characterized by a neuroendocrine phenotype and an aggressive clinical behavior. It frequentl......

Association of Hsp90 with p53 and Fizzy related homolog (Fzr) synchronizing Anaphase Promoting Complex (APC/C): An unexplored ally towards oncogenic pathway

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (3)

The intricate molecular interactions leading to the oncogenic pathway are the consequence of cell cycle modification controlled by a bunch of cell cyc......

MicroRNAs as important players in regulating cancer through PTEN/PI3K/AKT signalling pathways

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (3)

Cancer being the leading cause of mortality has become a great threat worldwide. Current cancer therapeutics lack specificity and have side effects du......

Extracellular vimentin as a versatile immune suppressive protein in cancer

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (6)

The interest in finding new targets in the tumor microenvironment for anti-cancer therapy has increased rapidly over the years. More specifically, the......

Modulating the gut microbiota by probiotics, prebiotics, postbiotics, and fecal microbiota transplantation: An emerging trend in cancer patient care

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (6)

Treatment resistance, together with acute and late adverse effects, represents critical issues in the management of cancer patients. Promising results......

RORγT agonists as immune modulators in anticancer therapy.

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (6)

ROR gamma T is a transcription factor that directs the development of Th17 lymphocytes and other IL-17-expressing cells (e.g., Tc17 and ILC3 cells). T......

Insights on the functional dualism of nitric oxide in the hallmarks of cancer

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023; 1878 (6)

Nitric oxide (NO), a gaseous radical, governs a variety of physiological and pathological processes, including cancer, pro-inflammatory signalling, an......

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