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The miR-200 family in normal mammary gland development

期刊: BMC DEVELOPMENTAL BIOLOGY, 2021; 21 (1)

The miR-200 family of microRNAs plays a significant role in inhibiting mammary tumor growth and progression, and its members are being investigated as......

Development of the indirect flight muscles of Aedes aegypti, a main arbovirus vector

期刊: BMC DEVELOPMENTAL BIOLOGY, 2021; 21 (1)

Background Flying is an essential function for mosquitoes, required for mating and, in the case of females, to get a blood meal and consequently funct......

Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling

期刊: BMC DEVELOPMENTAL BIOLOGY, 2021; 21 (1)

Background Mice with a loss of function mutation in Wdpcp were described previously to display severe birth defects in the developing heart, neural tu......

Changes in the expression levels of elastic fibres in yak lungs at different growth stages

期刊: BMC DEVELOPMENTAL BIOLOGY, 2021; 21 (1)

Background Yaks have a strong adaptability to the plateau environment, which can be attributed to the effective oxygen utilization rate of their lung ......

Natriuretic peptides and Forkhead O transcription factors act in a cooperative manner to promote cardiomyocyte cell cycle re-entry in the postnatal mouse heart

期刊: BMC DEVELOPMENTAL BIOLOGY, 2021; 21 (1)

Background Cardiomyocytes proliferate rapidly during fetal life but lose their ability of proliferation soon after birth. However, before terminal wit......

Dynamic conversion of cell sorting patterns in aggregates of embryonic stem cells with differential adhesive affinity

期刊: BMC DEVELOPMENTAL BIOLOGY, 2021; 21 (1)

Background: Mammalian early development comprises the proliferation, differentiation, and self-assembly of the embryonic cells. The classic experiment......

Effect of inorganic phosphate on migration and osteogenic differentiation of bone marrow mesenchymal stem cells

期刊: BMC DEVELOPMENTAL BIOLOGY, 2021; 21 (1)

Background: Phosphate is the major ingredient of bone tissue, and is also an important component of commercial bone substitute materials, bone scaffol......

Interleukin-6 promotes primitive endoderm development in bovine blastocysts

期刊: BMC DEVELOPMENTAL BIOLOGY, 2021; 21 (1)

Background: Interleukin-6 (IL6) was recently identified as an embryotrophic factor in bovine embryos, where it acts primarily to mediate inner cell ma......

Generation and identification of a conditional knockout allele for the PSMD11 gene in mice

期刊: BMC DEVELOPMENTAL BIOLOGY, 2021; 21 (1)

BackgroundOur previous study have shown that the PSMD11 protein was an important survival factor for cancer cells except for its key role in regulatio......

Etomoxir regulates the differentiation of male germ cells by specifically reducing H3K27ac level

期刊: BMC DEVELOPMENTAL BIOLOGY, 2021; 21 (1)

BackgroundFatty acid oxidation plays an important role in a variety of developing and mature organ systems. However, the role of this metabolic pathwa......

Knockdown of hspg2 is associated with abnormal mandibular joint formation and neural crest cell dysfunction in zebrafish

期刊: BMC DEVELOPMENTAL BIOLOGY, 2021; 21 (1)

Background Heparan sulfate proteoglycan 2 (HSPG2) encodes for perlecan, a large proteoglycan that plays an important role in cartilage formation, cell......

The migratory pathways of the cells that form the endocardium, dorsal aortae, and head vasculature in the mouse embryo

期刊: BMC DEVELOPMENTAL BIOLOGY, 2021; 21 (1)

Background Vasculogenesis in amniotes is often viewed as two spatially and temporally distinct processes, occurring in the yolk sac and in the embryo.......

Monocyte Chemoattractant Protein-1 stimulates the differentiation of rat stem and progenitor Leydig cells during regeneration

期刊: BMC DEVELOPMENTAL BIOLOGY, 2020; 20 (1)

Background Monocyte chemoattractant protein-1(MCP-1) is a chemokine secreted by Leydig cells and peritubular myoid cells in the rat testis. Its role i......

Differences among families in craniofacial shape at early life-stages of Arctic charr (Salvelinus alpinus)

期刊: BMC DEVELOPMENTAL BIOLOGY, 2020; 20 (1)

Background Organismal fitness can be determined at early life-stages, but phenotypic variation at early life-stages is rarely considered in studies on......

Depletion of SNRNP200 inhibits the osteo-/dentinogenic differentiation and cell proliferation potential of stem cells from the apical papilla

期刊: BMC DEVELOPMENTAL BIOLOGY, 2020; 20 (1)

Background: Tissue regeneration mediated by mesenchymal stem cells (MSCs) is deemed a desirable way to repair teeth and craniomaxillofacial tissue def......

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