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Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients

期刊: CELL REPORTS MEDICINE, 2022; 3 (4)

While immunopathology has been widely studied in patients with severe COVID-19, immune responses in non-hospitalized patients have remained largely el......

Anlotinib combined with TQB2450 in patients with platinum-resistant or -refractory ovarian cancer: A multi-center, single-arm, phase 1b trial

期刊: CELL REPORTS MEDICINE, 2022; 3 (7)

This is a phase Ib study of anlotinib plus a programmed death-ligand 1 (PD-L1) inhibitor TQB2450 for plat-inum-resistant or-refractory ovarian cancer.......

Antibody therapy reverses biological signatures of COVID-19 progression

期刊: CELL REPORTS MEDICINE, 2022; 3 (8)

Understanding who is at risk of progression to severe coronavirus disease 2019 (COVID-19) is key to clinical decision making and effective treatment. ......

Transcriptomics-based network medicine approach identifies metformin as a repurposable drug for atrial fibrillation

期刊: CELL REPORTS MEDICINE, 2022; 3 (10)

Effective drugs for atrial fibrillation (AF) are lacking, resulting in significant morbidity and mortality. This study demonstrates that network proxi......

Proteogenomic analysis of lung adenocarcinoma reveals tumor heterogeneity, survival determinants, and therapeutically relevant pathways

期刊: CELL REPORTS MEDICINE, 2022; 3 (11)

We present a deep proteogenomic profiling study of 87 lung adenocarcinoma (LUAD) tumors from the United States, integrating whole-genome sequencing, t......

Should Alexa diagnose Alzheimer's?: Legal and ethical issues with at-home consumer devices

期刊: CELL REPORTS MEDICINE, 2022; 3 (12)

Voice-based AI-powered digital assistants, such as Alexa, Siri, and Google Assistant, present an exciting op-portunity to translate healthcare from th......

Toward a more generalizable blood RNA signature for bacterial and viral infections

期刊: CELL REPORTS MEDICINE, 2022; 3 (12)

Host-response profiles can discriminate different infections. A new 8-gene blood RNA signature to discriminate bacterial and viral infections extends ......

Immunological factors, but not clinical features, predict visceral leishmaniasis relapse in patients co-infected with HIV

期刊: CELL REPORTS MEDICINE, 2022; 3 (1)

Visceral leishmaniasis (VL) has emerged as a clinically important opportunistic infection in HIV patients, as VL/HIV co-infected patients suffer from ......

Distinct immune cell dynamics correlate with the immunogenicity and reactogenicity of SARS-CoV-2 mRNA vaccine

期刊: CELL REPORTS MEDICINE, 2022; 3 (5)

Two doses of Pfizer/BioNTech BNT162b2 mRNA vaccine elicit robust severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing antibodies ......

Longitudinal characterization of circulating neutrophils uncovers phenotypes associated with severity in hospitalized COVID-19 patients

期刊: CELL REPORTS MEDICINE, 2022; 3 (10)

Mechanisms of neutrophil involvement in severe coronavirus disease 2019 (COVID-19) remain incompletely understood. Here, we collect longitudinal blood......

Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis

期刊: CELL REPORTS MEDICINE, 2022; 3 (11)

An increasing number of breast cancer patients develop brain metastases (BM). Standard-of-care treatments are largely inefficient, and breast cancer b......

Toward personalized immunotherapy in sepsis: The PROVIDE randomized clinical trial

期刊: CELL REPORTS MEDICINE, 2022; 3 (11)

The state of immune activation may guide targeted immunotherapy in sepsis. In a double-blind, double-dummy randomized clinical study, 240 patients wit......

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