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Natural Product-Based Drugs Discovery: Semisynthesis and Biological Evaluation of Ester Derivatives from Pregn-5-ene-3β,17a,20(S)-triol

期刊: CHEMICAL & PHARMACEUTICAL BULLETIN, 2023; 71 (3)

There is no doubt that derivation of intermediates from natural product is a very efficient way to develop new environmentally friendly pesticide. We ......

Anti-tumor Effect of Gambogenic Acid and Its Effect on CYP2C and CYP3A after Oral Administration

期刊: CHEMICAL & PHARMACEUTICAL BULLETIN, 2023; 71 (5)

Gambogenic acid (GNA), which has a broad spectrum of anti-tumor activity, is considered as a potential anticancer ingredient. In this study, we examin......

Syntheses of Aryl Thioethers via Aromatic Substitution of Aryl Halides at 0 to 25 °C

期刊: CHEMICAL & PHARMACEUTICAL BULLETIN, 2023; 71 (7)

In this study, we developed mild conditions for the synthesis of an aryl thioether via aromatic substitution using aryl halides, which is a process th......

Application of Granulated Nickel-Aluminum-Zirconium Complex Hydroxide in the Flow Method for Recovery of Chromium(VI) Ions

期刊: CHEMICAL & PHARMACEUTICAL BULLETIN, 2023; 71 (8)

A colloidal silicate granulated nickel-aluminum-zirconium (CSG-NAZ) was prepared, and the chromium(VI) (Cr(VI)) ions recovery capacity was evaluated u......

A Novel Amphotericin B Hydrogel Composed of Poly(Vinyl Alcohol)/Borate Complex for Ophthalmic Formulation

期刊: CHEMICAL & PHARMACEUTICAL BULLETIN, 2023; 71 (1)

In this study, we developed a water-soluble complex-hydrogel viscosity-controlled formulation of amphotericin B (AmB). AmB is insoluble in water, but ......

Noble-Metal-Free C-H Allylation of Tetrahydroisoquinolines Using a Cobalt- Organophotoredox Dual Catalyst System

期刊: CHEMICAL & PHARMACEUTICAL BULLETIN, 2023; 71 (2)

Metallaphotoredox-catalyzed allylation represents an emerging synthetic methodology that enables allylic substitu-tion using nucleophilic radical spec......

Studies on the Catechin Constituents of Bark of Cinnamomum sieboldii

期刊: CHEMICAL & PHARMACEUTICAL BULLETIN, 2023; 71 (5)

Screening for bioactivity related to anti-infective, anti-methicillin-resistant Staphylococcus aureus (MRSA) and anti-viral activity, led us to identi......

Application of in Silico Technologies for Drug Target Discovery and Pharmacokinetic Analysis

期刊: CHEMICAL & PHARMACEUTICAL BULLETIN, 2023; 71 (6)

Drug discovery is researched and developed through many processes, but its overall success rate is extremely low, requiring a very long period of deve......

Potential Interaction between Sodium Polystyrene Sulfonate and Prescription Drugs in Artificial Intestinal Juice

期刊: CHEMICAL & PHARMACEUTICAL BULLETIN, 2023; 71 (9)

This study evaluated the interaction between sodium polystyrene sulfonate (SPS) and several commonly used concomitant drugs, such as carvedilol, bisop......

Palatability Evaluation of Sulfamethoxazole/Trimethoprim with Sweetener Using the Two-Bottle Choice Test

期刊: CHEMICAL & PHARMACEUTICAL BULLETIN, 2023; 71 (12)

Drug taste, which affects palatability, influences drug adherence. Sensory masking may be used to confound bitter tastes in drugs with other tastes an......

Synthesis and Cytotoxicity Evaluation of Dehydroepiandrosterone Derivatives by Iron-Catalyzed Stereoselective Hydroamination

期刊: CHEMICAL & PHARMACEUTICAL BULLETIN, 2023; 71 (5)

The direct modification of structurally complex natural product dehydroepiandrosterone ( DHEA) through iron-catalyzed direct hydroamination of DHEA wi......

Origin of Large Near-Infrared Solvatochromism of 18E-Electron Aromatic Monohydroxybenziphthalocyanine

期刊: CHEMICAL & PHARMACEUTICAL BULLETIN, 2023; 71 (6)

Near-IR (NIR) organic dyes have been widely utilized in life sciences and materials science. Herein we report an unusually large NIR solvatochromism o......

Near-Infrared Fluorescence Enhancement by Deuteration of Phthalocyanine

期刊: CHEMICAL & PHARMACEUTICAL BULLETIN, 2023; 71 (6)

Organic compounds with near-IR (NIR) fluorescence have many potential applications in materials and life sciences, but the much weaker intensity of fl......

Angiotensin I-Converting Enzyme-Inhibitory Activity and Phytochemical Profile of Constituents of the Leaves of Rehmannia glutinosa f. hueichingensis

期刊: CHEMICAL & PHARMACEUTICAL BULLETIN, 2023; 71 (7)

The root of Rehmannia glutinosa Liboschitz forma hueichingensis HSIAO has been used as a tonic and treatment for urinary and skin disorders in Japanes......

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