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What can we learn from epidemiological studies on chronic boron exposure?

期刊: CRITICAL REVIEWS IN TOXICOLOGY, 2023; 53 (3)

Boric acid and sodium borates are classified as toxic to reproduction and development under category 1B, with the hazard statement of H360FD (May dama......

Weight of evidence evaluation for chemical-induced immunotoxicity for PFOA and PFOS: findings from an independent panel of experts

期刊: CRITICAL REVIEWS IN TOXICOLOGY, 2023; 53 (1)

Immunotoxicity is the critical endpoint used by the some regulatory agencyes to establish toxicity values for perfluorooctanoic acid (PFOA) and perflu......

Prevention and Detoxification of Mycotoxins in Human Food and Animal Feed using Bio-resources from South Mediterranean Countries: a Critical Review

期刊: CRITICAL REVIEWS IN TOXICOLOGY, 2023; 53 (2)

Mycotoxins, which are natural toxic compounds produced by filamentous fungi, are considered major contaminants in the food and feed chain due to their......

A review of pulmonary neutrophilia and insights into the key role of neutrophils in particle-induced pathogenesis in the lung from animal studies of lunar dusts and other poorly soluble dust particles

期刊: CRITICAL REVIEWS IN TOXICOLOGY, 2023; 53 (8)

The mechanisms of particle-induced pathogenesis in the lung remain poorly understood. Neutrophilic inflammation and oxidative stress in the lung are h......

Molecular insights into the role of electronic cigarettes in oral carcinogenesis

期刊: CRITICAL REVIEWS IN TOXICOLOGY, 2023; 53 (1)

Electronic cigarette (EC) usage or vaping has seen a significant rise in recent years across various parts of the world. They have been publicized as ......

Evidence and hypotheses on adverse effects of the food additives carrageenan (E 407)/processed Eucheuma seaweed (E 407a) and carboxymethylcellulose (E 466) on the intestines: a scoping review

期刊: CRITICAL REVIEWS IN TOXICOLOGY, 2023; 53 (9)

This scoping review provides an overview of publications reporting adverse effects on the intestines of the food additives carrageenan (CGN) (E 407)/p......

Hepatotoxicity due to dietary supplements: state-of-the-art, gaps and perspectives

期刊: CRITICAL REVIEWS IN TOXICOLOGY, 2023; 53 (10)

Food supplements are products intended to complement the normal diet and consist of concentrated sources of nutrients or other substances with a nutri......

The environment and male reproductive system: the potential role and underlying mechanisms of cadmium in testis cancer

期刊: CRITICAL REVIEWS IN TOXICOLOGY, 2023; 53 (7)

Cadmium is a known human carcinogen, and has been shown to profoundly affect male reproductive function, at multiple levels, by exerting both endocrin......

Acrylonitrile's genotoxicity profile: mutagenicity in search of an underlying molecular mechanism

期刊: CRITICAL REVIEWS IN TOXICOLOGY, 2023; 53 (2)

Acrylonitrile (ACN) is a known rodent and possible human carcinogen. There have also been concerns as to it causing adverse reproductive health effect......

Nephrotoxicity induced by natural compounds from herbal medicines - a challenge for clinical application

期刊: CRITICAL REVIEWS IN TOXICOLOGY, 2023; ()

Herbal medicines (HMs) have long been considered safe and effective without serious toxic and side effects. With the continuous use of HMs, more and m......

Toxicity of chemical-based hand sanitizers on children and the development of natural alternatives: a computational approach

期刊: CRITICAL REVIEWS IN TOXICOLOGY, 2023; 53 (9)

The unintended exposure of children to hand sanitizers poses a high risk of potentially fatal complications. Skin irritation, dryness, cracking, peeli......

Investigations on learning and memory function in extended one-generation reproductive toxicity studies - when considered needed and based on what?

期刊: CRITICAL REVIEWS IN TOXICOLOGY, 2023; ()

To justify investigations on learning and memory (L & M) function in extended one-generation reproductive toxicity studies (EOGRTS; Organization f......

Hazards of current concentration-setting practices in environmental toxicology studies

期刊: CRITICAL REVIEWS IN TOXICOLOGY, 2023; 53 (5)

The setting of concentrations for testing substances in ecotoxicological studies is often based on fractions of the concentrations that cause 50% mort......

Approaches for the setting of occupational exposure limits (OELs) for carcinogens

期刊: CRITICAL REVIEWS IN TOXICOLOGY, 2023; 53 (3)

This article addresses issues of importance for occupational exposure limits (OELs) and chemical carcinogens with a focus on non-threshold carcinogens......

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