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Lycopene as a Potential Bioactive Compound: Chemistry, Extraction, and Anticancer Prospective

期刊: CURRENT CANCER DRUG TARGETS, 2023; 23 (8)

Lycopene, a potential bioactive agent, is a non-pro-vitamin A carotenoid recognized as a potent antioxidant. It is extracted from plants like tomatoes......

Polyphyllin VII as a Potential Drug for Targeting Stemness in Hepatocellular Cancer via STAT3 Signaling

期刊: CURRENT CANCER DRUG TARGETS, 2023; 23 (4)

Background At present, the treatment of hepatocellular carcinoma (HCC) is disturbed by the treatment failure and recurrence caused by the residual liv......

Therapeutic Potential of Clostridium novyi-NT in Cancer: Current Knowledge and Future Perspectives

期刊: CURRENT CANCER DRUG TARGETS, 2023; 23 (9)

Resistance to conventional antitumour therapies and Hypoxia in patients with advanced solid tumours are two major reasons for the failure of conventio......

mRNA Vaccine-A New Cancer Treatment Strategy

期刊: CURRENT CANCER DRUG TARGETS, 2023; 23 (9)

The corresponding mRNA vaccines Comirnaty (BNT162b2) and Spikevax (mRNA-1273) have been authorized for emergency use since the COVID-19 outbreak. Most......

Recent Progress in Histone Deacetylase (HDAC) 1 Inhibitors as Anticancer Agent

期刊: CURRENT CANCER DRUG TARGETS, 2023; 23 (1)

Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing histone deacetylation. Aberrant expression of HDACs is associated......

Combination of Cefotaxime and Cisplatin Specifically and Selectively Enhances Anticancer Efficacy in Nasopharyngeal Carcinoma

期刊: CURRENT CANCER DRUG TARGETS, 2023; 23 (7)

Background HMOX1 has a dual role in cancers, especially involving chemoresistance. We demonstrate that cephalosporin antibiotics exert strong anticanc......

Role of miRNA-99a-5p in Modulating the Function of Hepatocellular Carcinoma Cells: Bioinformatics Analysis and in vitro Assay

期刊: CURRENT CANCER DRUG TARGETS, 2023; 23 (6)

Aim This study aimed to investigate the biological functions of miRNAs in hepatobiliary tumors as the focus of targeted therapy research. Background H......

Molecular Milieu of Autophagy in Cervical Cancer and its Therapeutic Implications

期刊: CURRENT CANCER DRUG TARGETS, 2023; 23 (11)

Cervical cancer is a common death-causing cancer among women in developing countries. Majority of the cases are triggered by persistent infections wit......

Research Advances of Clinical Application of Oncolytic Viruses in Treatment of Gynecologic Cancers

期刊: CURRENT CANCER DRUG TARGETS, 2023; 23 (7)

Oncolytic viruses (OVs) have become one of the main strategies of cancer biotherapy. They are genetically engineered or naturally occurring viruses th......

Serum Biomarker Panel for Rapid Early Diagnosis of Lung Cancer

期刊: CURRENT CANCER DRUG TARGETS, 2023; 23 (7)

Background: Lung cancer is the leading cause of cancer death in most countries. Although early diagnosis and treatment critically influence prognosis,......

Nanodiamond Mediated Molecular Targeting in Pancreatic Ductal Adenocarcinoma: Disrupting the Tumor-stromal Cross-talk, Next Hope on the Horizon?

期刊: CURRENT CANCER DRUG TARGETS, 2023; 23 (8)

Pancreatic ductal adenocarcinoma (PDAC) is one of the foremost causes of cancer-related morbidities worldwide. Novel nanotechnology-backed drug delive......

The DNMT3B Inhibitor Nanaomycin A as a Neuroblastoma Therapeutic Agent

期刊: CURRENT CANCER DRUG TARGETS, 2023; 23 (11)

Background: Neuroblastoma is one of the most common childhood solid tumors. Because tumor suppressor genes are often hypermethylated in cancers, DNA m......

Benzotriazole Substituted 2-Phenylquinazolines as Anticancer Agents: Synthesis, Screening, Antiproliferative and Tubulin Polymerization Inhibition Activity

期刊: CURRENT CANCER DRUG TARGETS, 2023; 23 (4)

Aims Development of anticancer agents targeting tubulin protein. Background Tubulin protein is being explored as an important target for anticancer dr......

Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) Plays an Oncogenic Role in Thyroid Carcinoma by Activating the AKT and ERK1/2 Signaling Pathway

期刊: CURRENT CANCER DRUG TARGETS, 2023; 23 (6)

Background Thyroid carcinoma (TC) is a common malignant tumor in human and its incidence has been increasing in recent years. Studies have shown that ......

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