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The Development of the Combination Drug Leukovir® Tablets for the Treatment of Multiple Sclerosis: A Comprehensive Review

期刊: CURRENT DRUG TARGETS, 2023; 24 (16)

The review is devoted to the development and study of the drug Leukovir (R) (cladribine+ribavirin) and its use in the treatment of relapsing-remitting......

Estimating the Survival Rate in Glioblastoma Multiforme Patients who Received a Peptide Vaccine: A Systematic Review and Meta-analysis

期刊: CURRENT DRUG TARGETS, 2023; 24 (12)

Introduction Glioblastoma Multiforme (GBM) has a poor prognosis, with current treatments providing no advantage in terms of survival. Certain new immu......

Inhibitors of Stimulator of Interferon Genes from 2019 to July 2022: An Overview of the Structure and Bioactivity

期刊: CURRENT DRUG TARGETS, 2023; 24 (12)

Stimulator of interferon genes (STING) plays a vital role in the human innate immune system. Aberrant expression of STING has been proven to be associ......

A Comprehensive Review on Nanomedicine: Promising Approach for Treatment of Brain Tumor through Intranasal Administration

期刊: CURRENT DRUG TARGETS, 2023; 24 (1)

Brain tumors have become one of the deadliest cancers; however, their treatment is still limited by conventional approaches. Brain tumors, among other......

Radical Scavenging, Anti-Inflammatory, and Hepatoprotective Activities of Pentacyclic Triterpene isolated from Rosa webbiana

期刊: CURRENT DRUG TARGETS, 2023; 24 (16)

Introduction: Rosa webbiana (RW) Wall Ex. Royle is used in traditional medicine in Pakistan for the treatment of several diseases including jaundice. ......

An Update on Autophagy as a Target in the Treatment of Alzheimer's Disease

期刊: CURRENT DRUG TARGETS, 2023; 24 (7)

Proteostasis is crucial for the maintenance and proper operation of cells. Under typical circumstances, the ubiquitin-proteasome system (UPS) and the ......

Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases

期刊: CURRENT DRUG TARGETS, 2023; 24 (15)

Pyroptosis has become a noteworthy area of focus in recent years due to its association with inflammatory diseases. Pyroptosis is a type of programmed......

The Role of CDK20 Protein in Carcinogenesis

期刊: CURRENT DRUG TARGETS, 2023; 24 (10)

Cancer is a complex disease that develops when abnormal cells divide uncontrollably as a consequence of unregulated cell cycle protein activity. There......

Parasite Metalo-aminopeptidases as Targets in Human Infectious Diseases

期刊: CURRENT DRUG TARGETS, 2023; 24 (5)

Background Parasitic human infectious diseases are a worldwide health problem due to the increased resistance to conventional drugs. For this reason, ......

Rho Kinase (ROCK) Inhibitors for the Treatment of Glaucoma

期刊: CURRENT DRUG TARGETS, 2023; ()

Glaucoma is the most common cause of irreversible blindness worldwide. It is characterized by progressive optic nerve degeneration and loss of visual ......

Epileptic Targets and Drugs: A Mini-Review

期刊: CURRENT DRUG TARGETS, 2023; 24 (3)

Background: Epilepsy is a neurological disease affected by an imbalance of inhibitory and excitatory signaling in the brain. Introduction: In this dis......

MiRNAs Overexpression and Their Role in Breast Cancer: Implications for Cancer Therapeutics

期刊: CURRENT DRUG TARGETS, 2023; 24 (6)

MicroRNAs have a plethora of roles in various biological processes in the cells and most human cancers have been shown to be associated with dysregula......

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