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Potent Lipophilic Melatoninergic x-fluoro-y-methoxy Substituted Phenylalkylamides: Molecular Dynamics Calculations and in vitro Modified Release in Aqueous Media from Tablet Formulations

期刊: CURRENT PHARMACEUTICAL DESIGN, 2023; 29 (17)

Introduction We report herein on the design and development of matrix tablets containing potent synthetic melatonin (MLT) receptor analogues, the x-fl......

Can Brain-derived Neurotrophic Factor (BDNF) Mimetics be a Way Out for Neurodegenerative Diseases?

期刊: CURRENT PHARMACEUTICAL DESIGN, 2023; 29 (4)

Neurodegenerative diseases are chronic and progressive disease groups characterized by the decline of neural transmission because of the loss of struc......

miR-628-5p is a Potential Novel Prognosis Biomarker, Associated with Immune Infiltration in Bladder Urothelial Carcinoma

期刊: CURRENT PHARMACEUTICAL DESIGN, 2023; 29 (31)

Background: microRNA-628-5p (miR-628-5p) has a significant impact on certain types of cancer. The precise function of miR-628-5p in the context of bla......

Icacinaceae Plant Family: A Recapitulation of the Ethnobotanical, Phytochemical, Pharmacological, and Biotechnological Aspects

期刊: CURRENT PHARMACEUTICAL DESIGN, 2023; 29 (15)

Icacinaceae, an Angiospermic family comprising 35 genera and 212 accepted species, including trees, shrubs, and lianas with pantropical distribution, ......

The Interplay Between Gut Microbiota and Central Nervous System

期刊: CURRENT PHARMACEUTICAL DESIGN, 2023; 29 (41)

This review highlights the relationships between gastrointestinal microorganisms and the brain. The gut microbiota communicates with the central nervo......

An In-silico Approach to Design and Validate siRNA against Monkeypox Virus

期刊: CURRENT PHARMACEUTICAL DESIGN, 2023; 29 (38)

Introduction: The monkeypox virus has emerged as an uncommon zoonotic infection. The recent outbreak of MPXV in Europe and abroad in 2022 presented a ......

Microsponges as Drug Delivery System: Past, Present, and Future Perspectives

期刊: CURRENT PHARMACEUTICAL DESIGN, 2023; 29 (13)

Microsponges are polymeric delivery devices composed of porous microspheres that range in size from 5 to 300 micrometers. These have been explored for......

Low Dose Olanzapine in the Prevention and Treatment of Carboplatin Induced Nausea and Vomiting: A Prospective Clinical Randomized Controlled Trial

期刊: CURRENT PHARMACEUTICAL DESIGN, 2023; 29 (23)

Objective: This study aimed to determine the effectiveness and safety of 5 mg olanzapine (OLZ) in preventing vomiting and nausea caused by carboplatin......

Exploration of Molecular Targets and Mechanisms of Curcumin in the Treatment of COVID-19 with Depression by an Integrative Pharmacology Strategy

期刊: CURRENT PHARMACEUTICAL DESIGN, 2023; 29 (31)

Background Coronavirus disease 2019 (COVID-19) not only causes a range of respiratory symptoms but also has a great impact on individual mental health......

Tools to Evaluate the Eco-efficiency of Analytical Methods in the Context of Green and White Analytical Chemistry: A Review

期刊: CURRENT PHARMACEUTICAL DESIGN, 2023; 29 (31)

Background The release of a product in the consumer market requires an analysis by quality control. This sector makes use of reliable analytical metho......

New Generation Smart Drug Delivery Systems for Rheumatoid Arthritis

期刊: CURRENT PHARMACEUTICAL DESIGN, 2023; 29 (13)

Rheumatoid arthritis (RA) is the most common form of the chronic inflammatory autoimmune disease characterized by chronic synovitis, synovial prolifer......

Cytotoxic and DNA-binding Capacity of Titanocene Functionalized Mesoporous Nanoparticles in Breast Cancer Cell Lines MCF-7 and MDA-MB-231

期刊: CURRENT PHARMACEUTICAL DESIGN, 2023; 29 (22)

Aims The fight against cancer is an active research topic that combines several disciplines to find suitable agents to treat various tumours.Backgroun......

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