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Synergistic roles of the phospholipase B homolog Plb1 and the cAMP-dependent protein kinase Pka1 in the hypertonic stress response of Schizosaccharomyces pombe

期刊: CURRENT GENETICS, 2022; 68 (5-6)

The phospholipase B homolog Plb1 and the cAMP-dependent protein kinase (PKA) pathway are required by fission yeast, also known as to Schizosaccharomyc......

JIF:3.695

Off-target effects of base editors: what we know and how we can reduce it

期刊: CURRENT GENETICS, 2022; 68 (1)

The recently discovered CRISPR-Cas9 modification, base editors (BEs), is considered as one of the most promising tools for correcting disease-causing ......

JIF:3.695

Transcriptional repressor Gal80 recruits corepressor complex Cyc8-Tup1 to structural genes of the Saccharomyces cerevisiae GAL regulon

期刊: CURRENT GENETICS, 2022; 68 (1)

Under non-inducing conditions (absence of galactose), yeast structural genes of the GAL regulon are repressed by Gal80, preventing interaction of Gal4......

JIF:3.695

Variable penetrance of Nab3 granule accumulation quantified by a new tool for high-throughput single-cell granule analysis

期刊: CURRENT GENETICS, 2022; 68 (3-4)

Reorganization of cellular proteins into subcellular compartments, such as the concentration of RNA-binding proteins into cytoplasmic stress granules ......

JIF:3.695

A novel Zn-2-Cys(6) transcription factor clcA contributes to copper homeostasis in Aspergillus fumigatus

期刊: CURRENT GENETICS, 2022; 68 (5-6)

The filamentous fungus Aspergillus fumigatus is the most important pathogenic fungus among Aspergillus species associated with aspergillosis. A. fumig......

JIF:3.695

NDK/NME proteins: a host-pathogen interface perspective towards therapeutics

期刊: CURRENT GENETICS, 2022; 68 (1)

No effective vaccine is available for any parasitic disease. The treatment to those is solely dependent on chemotherapy, which is always threatened du......

JIF:3.695

Suggestion for a new bacteriophage genus for the Klebsiella pneumoniae phage vB_KpnS-Carvaje

期刊: CURRENT GENETICS, 2022; 68 (3-4)

This work describes the newly isolated Klebsiella pneumoniae phage vB_KpnS-Carvaje that presents unique features in relation to other phages reported ......

JIF:3.695

Wide mutational analysis to ascertain the functional roles of eL33 in ribosome biogenesis and translation initiation

期刊: CURRENT GENETICS, 2022; 68 (5-6)

An extensive mutational analysis of RPL33A, encoding the yeast ribosomal protein L33A (eL33) allowed us to identify several novel rpl33a mutants with ......

JIF:3.695

Transcriptional noise adjusted for expression levels reveals genes with high transcriptional noise that are highly expressed, functionally related, and co-regulated in yeast

期刊: CURRENT GENETICS, 2022; 68 (5-6)

Understanding the relationship between variability in single-cell and non-single-cell gene expression studies will aid in understanding the role of an......

JIF:3.695

Insertion orientation within the cassette affects gene-targeting success during ends-out recombination in the yeast Saccharomyces cerevisiae

期刊: CURRENT GENETICS, 2022; 68 (5-6)

Gene-targeting is one of the most important molecular tools for genomic manipulations for research and industrial purposes. However, many factors infl......

JIF:3.695

Dysfunction of Ras-GAP protein AfgapA contributes to hypoxia fitness in Aspergillus fumigatus

期刊: CURRENT GENETICS, 2022; 68 (5-6)

The filamentous fungus Aspergillus fumigatus is the most important pathogenic fungus among Aspergillus species associated with aspergillosis. A. fumig......

JIF:3.695

Increased peroxisome proliferation is associated with early yeast replicative ageing

期刊: CURRENT GENETICS, 2022; 68 (2)

Peroxisomes are single membrane-bound organelles ubiquitously present in several cell types and are associated with cell and tissue-specific functions......

JIF:3.695

Application of recyclable CRISPR/Cas9 tools for targeted genome editing in the postharvest pathogenic fungi Penicillium digitatum and Penicillium expansum

期刊: CURRENT GENETICS, 2022; 68 (3-4)

Penicillium digitatum and Penicillium expansum are plant pathogenic fungi that cause the green and blue mold diseases, respectively, leading to seriou......

JIF:3.695

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