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Critical considerations in N-glycoproteomics

期刊: CURRENT OPINION IN CHEMICAL BIOLOGY, 2023; 73 ()

N-Glycoproteomics, the system-wide study of glycans asparagine-linked to protein carriers, holds a unique and still largely untapped potential to prov......

Tuning specificity and topology of lectins through synthetic biology

期刊: CURRENT OPINION IN CHEMICAL BIOLOGY, 2023; 73 ()

Lectins are non-immunoglobulin and non-catalytic glycan binding proteins that are able to decipher the structure and function of complex glycans. They......

Multi-omics approaches to study platelet mechanisms

期刊: CURRENT OPINION IN CHEMICAL BIOLOGY, 2023; 73 ()

Platelets are small anucleate cell fragments (2-4 mm in diameter) in the blood, which play an essential role in throm-bosis and hemostasis. Genetic or......

Small-molecule organoselenocyanates: Recent developments toward synthesis, anticancer, and antioxidant activities

期刊: CURRENT OPINION IN CHEMICAL BIOLOGY, 2023; 75 ()

Cellular redox homeostasis is very important for the overall cellular development, function, and oxidative stress often disrupts the process. Small-mo......

Nutritional metabolomics: Recent developments and future needs

期刊: CURRENT OPINION IN CHEMICAL BIOLOGY, 2023; 77 ()

Metabolomics has rapidly been adopted as one of the key methods in nutrition research. This review focuses on the recent developments and updates in t......

The influence of alkylating agents on sulfur-sulfur bonds in per- and polysulfides

期刊: CURRENT OPINION IN CHEMICAL BIOLOGY, 2023; 76 ()

Per- and polysulfides are sulfane sulfur species produced inside living cells, in organisms as diverse as bacteria, plants and humans, but their biolo......

Targeting chemotherapy-resistant tumour sub-populations using inorganic chemistry: Anti-cancer stem cell metal complexes

期刊: CURRENT OPINION IN CHEMICAL BIOLOGY, 2023; 72 ()

Cancer stem cells (CSC) are a sub-population of tumours linked to metastasis and relapse. Current chemotherapeutic drug options are ineffective agains......

How do metabolic processes age: Evidence from human metabolomic studies

期刊: CURRENT OPINION IN CHEMICAL BIOLOGY, 2023; 76 ()

Metabolomics, the global profiling of small molecules in the body, has emerged as a promising analytical approach for assessing molecular changes asso......

Highlights of bioinformatic tools and methods for validating bioinformatics derived hypotheses for microbial natural products research

期刊: CURRENT OPINION IN CHEMICAL BIOLOGY, 2023; 76 ()

Historically, bacterial natural products have served as an excellent source of drug leads, however, in recent decades the rate of discovery has slowed......

Redox regulation of defense against bacterial and viral pathogens

期刊: CURRENT OPINION IN CHEMICAL BIOLOGY, 2023; 76 ()

There is considerable interest in the role of oxygen-derived oxidants (often termed generically reactive oxygen species), and the potential effect of ......

Platinum glycoconjugates: Sweet bullets for targeted cancer therapy?

期刊: CURRENT OPINION IN CHEMICAL BIOLOGY, 2023; 72 ()

Cancer, which is characterized by uncontrolled proliferation of abnormal cells, is a leading cause of morbidity and mortality worldwide. Cytotoxic che......

Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes

期刊: CURRENT OPINION IN CHEMICAL BIOLOGY, 2023; 74 ()

The enzymatic breakdown of carbohydrates plays a critical role in several biological events and enables the development of sustainable processes to ob......

The multifaceted nature of peroxiredoxins in chemical biology

期刊: CURRENT OPINION IN CHEMICAL BIOLOGY, 2023; 76 ()

Peroxiredoxins (Prx), thiol-dependent peroxidases, were first identified as H2O2 detoxifiers, and more recently as H2O2 sensors, intermediates in redo......

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