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Biochemical and histopathological analysis after sub-chronic administration of oxyresveratrol in Wistar rats

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; 46 (1)

Oxyresveratrol (OXY) is a naturally occurring phenolic compound; however, there are no toxicity studies reported on its long term use. The aim of our ......

Exposure to emamectin benzoate confers cytotoxic effects on human molt-4 T-cells and possible ameliorative role of vitamin E and dithiothreitol

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; 46 (3)

Emamectin benzoate (EMB) is an avermectin insecticide that is extensively used for pest control, but there are few reports concerning its cytotoxic ef......

Pre-imaginal exposure to mancozeb induces morphological and behavioral deficits and oxidative damage in Drosophila melanogaster

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; 46 (3)

Mancozeb (MZ), a manganese/zinc containing ethylene-bis-dithiocarbamate, is a broad-spectrum fungicide. Chronic exposure to MZ has been related to sev......

Effect of Salvia officinalis aqueous infusion on copper sulfate-induced inflammatory response and oxidative stress imbalance in mice liver and kidney

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; ()

Extracts of Salvia officinalis (S. officinalis) have been described to have many therapeutic properties. However, the effect of S. officinalis on copp......

Long-term toxicity of fluoroquinolones: a comprehensive review

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; ()

Fluoroquinolones (FQs) are highly potent bactericidal antibiotics with broad-spectrum activity against Gram-negative/positive bacteria. The Food and D......

Anti-ischemic drug trimetazidine blocks mercury nephrotoxicity by suppressing renal redox imbalance, inflammatory stress and caspase-dependent apoptosis in rats

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; ()

Trimetazidine (TMZ) is a promising emerging therapeutic piperazine derivative for renal pathologies. However, the nephroprotective mechanism of TMZ ag......

Modulatory effect of myricitrin against chromosome instability and cytostasis induced by bleomycin and oxaliplatin in CHO-K1 cells

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; 46 (4)

Myricitrin (MYR), a flavonol consumed in the leaves and fruits of plants of the Myrtaceae family, presents anti-proliferative, anti-inflammatory, anti......

Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by α-naphthylthiourea

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; 46 (5)

We aimed to observe the possible effects of melatonin (MLT) deprivation (pinealectomy) and exogenous MLT administration on pulmonary edema induced by ......

Co-administration of thymol and sulfoxaflor impedes the expression of reproductive toxicity in male rats

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; ()

This study investigated the capability of a co-delivery system of thymol (THY) and sulfoxaflor that can serve to minimize the development of epididyma......

Hepatoprotective effects of norgalanthamine on carbon tetrachloride induced-hepatotoxicity in mice

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; 46 (1)

Norgalanthamine is a major component of Crinum asiaticum var. japonicum that exhibits several biological activities. This study evaluated the anti-inf......

Evaluating Water bitter leaf (Struchium sparganophora) and Scent Leaf (Ocimum gratissimum) extracts as sources of nutraceuticals against manganese-induced toxicity in fruit fly model

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; 46 (2)

Tropical vegetables remain one of the major sources of functional foods and nutraceuticals, while their constituent phytochemicals, especially alkaloi......

Evaluation of immunological adjuvant activities of saponin rich fraction from the fruits of Asparagus adscendens Roxb. with less adverse reactions

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; 46 (3)

The hemolytic activity, in vitro as well as in vivo toxicity, and immunomodulatory potential of saponins-rich fraction of Asparagus adscendens Roxb. f......

Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; 46 (3)

Isorhamnetin is a hepatoprotective flavonoid molecule derived from the leaves and fruits of Hippophae rhamnoides L. However, the protective effect of ......

The preventive effects of Centaurea maroccana Ball. extract against oxidative stress induced by cisplatin in mice brains: in vitro and in vivo studies

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; 46 (6)

Since antiquity, Centaurea species have been used in folk medicine to treat several diseases owing to their potential biological activities that disti......

Combination of metformin and sub-therapeutic dose of valproic acid prevent valproic acid-induced toxicity in animal model of epilepsy

期刊: DRUG AND CHEMICAL TOXICOLOGY, 2023; ()

Valproic acid (VPA) is one of the most prescribed drugs for epilepsy. Extended use of VPA not only induces hepatotoxicity but also impairs the cogniti......

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