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An actin remodeling role for Arabidopsis processing bodies revealed by their proximity interactome

期刊: EMBO JOURNAL, 2023; 42 (9)

Cellular condensates can comprise membrane-less ribonucleoprotein assemblies with liquid-like properties. These cellular condensates influence various......

Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys

期刊: EMBO JOURNAL, 2023; 42 (9)

Human in vitro oogenesis provides a framework for clarifying the mechanism of human oogenesis. To create its benchmark, it is vital to promote in vitr......

TFEB-dependent lysosome biogenesis is required for senescence

期刊: EMBO JOURNAL, 2023; 42 (9)

The accumulation of senescent cells is recognised as a driver of tissue and organismal ageing. One of the gold-standard hallmarks of a senescent cell ......

LncRNA LITATS1 suppresses TGF-β-induced EMT and cancer cell plasticity by potentiating TβRI degradation

期刊: EMBO JOURNAL, 2023; 42 (10)

Epithelial cells acquire mesenchymal phenotypes through epithelial-mesenchymal transition (EMT) during cancer progression. However, how epithelial cel......

Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation

期刊: EMBO JOURNAL, 2023; 42 (16)

Meiotic recombination is initiated by the formation of DNA double-strand breaks (DSBs), essential for fertility and genetic diversity. In the mouse, D......

Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome

期刊: EMBO JOURNAL, 2023; 42 (20)

Mitochondrial DNA (mtDNA) leakage into the cytoplasm can occur when cells are exposed to noxious stimuli. Specific sensors recognize cytoplasmic mtDNA......

MICa/b-dependent activation of natural killer cells by CD64+inflammatory type 2 dendritic cells contributes to autoimmunity

期刊: EMBO JOURNAL, 2023; 42 (23)

Primary Sj & ouml;gren's syndrome (pSS) is an inflammatory autoimmune disorder largely mediated by type I and II interferon (IFN). The potential c......

Translational regulation by Hfq-Crc assemblies emerges from polymorphic ribonucleoprotein folding

期刊: EMBO JOURNAL, 2023; 42 (3)

The widely occurring bacterial RNA chaperone Hfq is a key factor in the post-transcriptional control of hundreds of genes in Pseudomonas aeruginosa. H......

A systematic proximity ligation approach to studying protein-substrate specificity identifies the substrate spectrum of the Ssh1 translocon

期刊: EMBO JOURNAL, 2023; 42 (11)

Many cellular functions are carried out by protein pairs or families, providing robustness alongside functional diversity. For such processes, it rema......

The ASC-1 complex promotes translation initiation by scanning ribosomes

期刊: EMBO JOURNAL, 2023; 42 (12)

Translation initiates when the eIF4F complex binds the 5 ' mRNA cap, followed by 5 ' untranslated region scanning for the start codon by scanning ribo......

Phospholipid scramblase Xkr8 is required for developmental axon pruning via phosphatidylserine exposure

期刊: EMBO JOURNAL, 2023; 42 (14)

The mature mammalian brain connectome emerges during development via the extension and pruning of neuronal connections. Glial cells have been identifi......

Viral recognition and the antiviral interferon response

期刊: EMBO JOURNAL, 2023; 42 (14)

Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response to viral infections. In response to viral stimuli, cells......

The diverging role of CDC14B: from mitotic exit in yeast to cell fate control in humans

期刊: EMBO JOURNAL, 2023; 42 (16)

CDC14, originally identified as crucial mediator of mitotic exit in budding yeast, belongs to the family of dual-specificity phosphatases (DUSPs) that......

Replication-induced DNA secondary structures drive fork uncoupling and breakage

期刊: EMBO JOURNAL, 2023; ()

Sequences that form DNA secondary structures, such as G-quadruplexes (G4s) and intercalated-Motifs (iMs), are abundant in the human genome and play va......

Be sustainable: EOSC-Life recommendations for implementation of FAIR principles in life science data handling

期刊: EMBO JOURNAL, 2023; 42 (23)

The main goals and challenges for the life science communities in the Open Science framework are to increase reuse and sustainability of data resource......

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