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Designing the 5HT2BR structure and its modulation as a therapeutic target for repurposing approach in drug-resistant epilepsy

期刊: EPILEPSY RESEARCH, 2023; 194 ()

The study intends to repurpose FDA drugs and investigate the mechanism of (5HT2BR) activation by compre-hending inter-residue interactions. The 5HT2BR......

Impact of JME on quality of life: Does a well-controlled epilepsy also hamper the psychological wellbeing?

期刊: EPILEPSY RESEARCH, 2023; 194 ()

Purpose: Epilepsy is a stigmatizing disorder and its diagnosis can have important psychosocial consequences on individuals, severely impacting their q......

Long-term follow-up of phenobarbital versus valproate for generalized convulsive status epilepticus in adults: A randomized clinical trial

期刊: EPILEPSY RESEARCH, 2023; 195 ()

Objective: Intravenous phenobarbital is frequently offered to patients with generalized convulsive status epilepticus (GCSE) in China, but its long-te......

The initial treatment in convulsive status epilepticus in China: A multi-center observational study

期刊: EPILEPSY RESEARCH, 2023; 197 ()

Objective: To investigate the initial treatment of patients with convulsive status epilepticus (CSE) in a resource limited region of China, and to dis......

Seizure outcomes and safety profiles of surgical options for epilepsy associated to hypothalamic hamartomas. A systematic review and meta-analysis

期刊: EPILEPSY RESEARCH, 2023; 198 ()

Purpose: Several surgical options are available for treating hypothalamic hamartoma-related epilepsy but their respective efficacy and safety profiles......

Basal temporal lobe epilepsy: SEEG electroclinical characteristics

期刊: EPILEPSY RESEARCH, 2023; 191 ()

Objective: Temporal lobe epilepsy is the most common type of focal drug-resistant epilepsy. Seizures with pre-dominant involvement of basal temporal r......

Circulating miR-146a-5p and miR-132-3p as potential diagnostic biomarkers in epilepsy

期刊: EPILEPSY RESEARCH, 2023; 191 ()

Objective: MiRNAs are important gene-regulating agents in epilepsy development, according to new research. The purpose of this study is to investigate......

Long-term outcomes of classic and novel anti-seizure medication in a kainate-induced model of chronic epilepsy

期刊: EPILEPSY RESEARCH, 2023; 191 ()

Objective: Intrahippocampal injection of kainate (KA) is a reliable model of temporal lobe epilepsy (TLE) that replicates spontaneous recurrent seizur......

Frontoparietal 18F-FDG-PET hypo-metabolism in Lennox-Gastaut syndrome: Further evidence highlighting the key network

期刊: EPILEPSY RESEARCH, 2023; 192 ()

Introduction: Lennox Gastaut syndrome (LGS) can be conceptualised as a secondary network epilepsy, in which the shared electroclinical manifestations ......

Epilepsy following herpes simplex encephalitis-A case series

期刊: EPILEPSY RESEARCH, 2023; 192 ()

Background: Herpes simplex encephalitis (HSE) is associated with severe mortality and morbidity. Its incidence is estimated at 1:250 000, and the typi......

Adjunct antiseizure effect of clotrimazole in a rotenone corneal kindling mouse model of mitochondrial drug-resistant epilepsy

期刊: EPILEPSY RESEARCH, 2023; 198 ()

This study aimed to investigate the therapeutic potential of clotrimazole, an inhibitor of the transient receptor potential cation channel, for treati......

Bioinformatics and network pharmacology analysis of drug targets and mechanisms related to the comorbidity of epilepsy and migraine

期刊: EPILEPSY RESEARCH, 2023; 189 ()

Objective: The present study aimed to explore the mechanisms underlying the comorbidity of epilepsy and migraine, identify potential common targets fo......

Magnetoencephalographic spikes with small spikes on simultaneous electroencephalography have high spatial clustering in temporal lobe epilepsy

期刊: EPILEPSY RESEARCH, 2023; 192 ()

Objective: To classify magnetoencephalographic (MEG) spikes according to the findings of simultaneous scalp electroencephalography (EEG) to study dipo......

Resting-state fMRI in patients with refractory epilepsy with and without drop attacks: exploring the connectivity of sensorimotor cortex

期刊: EPILEPSY RESEARCH, 2023; 197 ()

Objective: Patients with multifocal or generalized epilepsies manifesting with drop attacks have severe refractory seizures and significant cognitive ......

Protein profiling in plasma for biomarkers of seizure

期刊: EPILEPSY RESEARCH, 2023; 197 ()

Purpose: A biochemical way to measure seizures would greatly benefit epilepsy research and clinical follow-up. Short-term biomarkers like lactate exis......

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