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NKG2D engagement on human NK cells leads to DNAM-1 hypo-responsiveness through different converging mechanisms

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2023; 53 (2)

Natural killer (NK) cell activation is regulated by activating and inhibitory receptors that facilitate diseased cell recognition. Among activating re......

Staphylococcus aureus-derived factors promote human Th9 cell polarization and enhance a transcriptional program associated with allergic inflammation

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2023; 53 (3)

T helper (Th) 9 cells, characterized by robust secretion of IL-9, have been increasingly associated with allergic diseases. However, whether and how T......

Foxp3+ regulatory T cells in the central nervous system and other nonlymphoid tissues

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2023; ()

Foxp3(+) regulatory T (Treg) cells are indispensable for the maintenance of immunologic self-tolerance as well as for the confinement of autoimmune in......

The G allele of SNP rs3922 reduces the binding affinity between IGF2BP3 and CXCR5 correlating with a lower antibody production

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2023; ()

Effective vaccines that function through humoral immunity seek to produce high-affinity antibodies. Our previous research identified the single-nucleo......

Mesenchymal stromal cells and their small extracellular vesicles in allergic diseases: From immunomodulation to therapy

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2023; 53 (10)

Mesenchymal stromal cells (MSCs) have long been considered a potential tool for treatment of allergic inflammatory diseases, owing to their immunomodu......

SIRPa: A key player in innate immunity

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2023; ()

Signal regulatory protein alpha (SIRPa) is a crucial inhibitory regulator expressed on the surface of myeloid cells, including macrophages, dendritic ......

Inactivated whole virion vaccine protects K18-hACE2 Tg mice against the Omicron SARS-CoV-2 variant via cross-reactive T cells and nonneutralizing antibody responses

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2023; ()

COVID-19 is a systemic inflammatory disease initiated by SARS-CoV-2 virus infection. Multiple vaccines against the Wuhan variant of SARS-CoV-2 have be......

The thioredoxin system: Balancing redox responses in immune cells and tumors

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2023; 53 (1)

The thioredoxin (TRX) system is an important contributor to cellular redox balance and regulates cell growth, apoptosis, gene expression, and antioxid......

Targeting glycogen synthase kinase 3 with CHIR99021 negatively regulates allergen-induced mast cell activation

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2023; 53 (1)

Mast cells are granulated immune sentinels responsible for allergic inflammation. Allergen-induced Fc epsilon RI-signaling leads to rapid degranulatio......

PGE2 expression by HPV6/11-induced respiratory papillomas blocks NK cell activation in patients with recurrent respiratory papillomatosis

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2023; 53 (4)

Recurrent respiratory papillomatosis (RRP), a rare chronic disease caused primarily by human papillomavirus types 6 and 11, consists of repeated growt......

Training the microbiota to increase immune checkpoint blockade and to reduce toxicity

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2023; ()

There is no doubt that immunotherapy, particularly immune checkpoint blockade (ICB), has drastically improved treatment of metastatic cancer patients.......

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