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An electrophysiological method for evaluation of topical antipruritic drugs on itch-related neuronal activities in the spinal cord in hairless mice

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 952 ()

To evaluate the effects of antipruritic drugs, it is important to determine whether the neural responses induced by physiological itch stimuli are sup......

Super-enhancer-driven lncRNA Snhg7 aggravates cardiac hypertrophy via Tbx5/GLS2/ferroptosis axis

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 953 ()

Long non-coding RNAs (lncRNAs) are expressed aberrantly in cardiac disease, but their roles in cardiac hyper-trophy are still unknown. Here we sought ......

1,8-Cineole ameliorates endothelial injury and hypertension induced by L-NAME through regulation of autophagy via PI3K/mTOR signaling pathway

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 954 ()

Our previous data confirmed that 1,8-Cineole had an antihypertensive effect in animal models. However, it is unclear whether antihypertension is depen......

NMDA receptor inhibitor MK801 alleviated pro-inflammatory polarization of BV-2 microglia cells

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 955 ()

Microglia have both protective and pathogenic properties, while polarization plays a decisive role in their functional diversity. Apart from being an ......

Anandamide reduces the migration of lymphocytes to the intestine by CB2 activation and reduces TNF-a in the target organs, protecting mice from graft-versus-host disease

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 956 ()

Graft-versus-host disease (GVHD) is a serious inflammatory illness that often occurs as a secondary complication of bone marrow transplantation. Curre......

Prefrontal cortex-specific Dcc deletion induces schizophrenia-related behavioral phenotypes and fail to be rescued by olanzapine treatment

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 956 ()

Multiple genome studies have discovered that variation in deleted in colorectal carcinoma (Dcc) at transcription and translation level were associated......

Downregulation of PDCD4 through STAT3/ATF6/autophagy mediates MIF-induced PASMCs proliferation/migration and vascular remodeling

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 956 ()

To address the molecular mechanisms underlying macrophage migration inhibitory factor (MIF) induced pul-monary artery smooth muscle cells (PASMCs) pro......

4D-DIA quantitative proteomics revealed the core mechanism of diabetic retinopathy after berberine treatment

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 958 ()

Objective: To reveal the core mechanism of berberine (BBR) in the treatment of diabetic retinopathy (DR), by using Four-dimensional independent data a......

Overcoming the compensatory increase in NRF2 induced by NPL4 inhibition enhances disulfiram/copper-induced oxidative stress and ferroptosis in renal cell carcinoma

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 960 ()

Renal cell carcinoma (RCC) is the most common type of kidney cancer, and it appears to be highly susceptible to ferroptosis. Disulfiram, an alcoholism......

Stabilization of mitochondrial function by chlorogenic acid protects against kainic acid-induced seizures and neuronal cell death in rats

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 961 ()

The current study investigated the effect of chlorogenic acid, a polyphenolic compound found in numerous plant products, on a kainic acid-induced seiz......

Cryptotanshinone modulates proliferation, apoptosis, and fibrosis through inhibiting AR and EGFR/STAT3 axis to ameliorate benign prostatic hyperplasia progression

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 938 ()

Benign prostatic hyperplasia (BPH) is a chronic proliferative non-tumorous disease that mainly bothers males older than 50 and significantly disturbs ......

Administration of Huperzine A microspheres ameliorates myocardial ischemic injury via α7nAChR-dependent JAK2/STAT3 signaling pathway

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 940 ()

Acetylcholinesterase (AChE) inhibitor (AChEI) is well established as first-line agents for relieving the symptoms of Alzheimer's disease (AD). Injecta......

Activation of angiotensin II type 2 receptor attenuates lung injury of collagen-induced arthritis by alleviating endothelial cell injury and promoting Ly6Clo monocyte transition

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 941 ()

As one of the most frequent extra-articular manifestations of rheumatoid arthritis (RA), interstitial lung disease (ILD) is still challenging due to u......

Sertaconazole nitrate targets IDO1 and regulates the MAPK signaling pathway to induce autophagy and apoptosis in CRC cells

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 942 ()

Colorectal cancer (CRC) has become the third most frequently occurring malignant tumor worldwide. It is vital to identify novel, effective targeted tr......

Inhibition of TRPM8 by the urinary tract analgesic drug phenazopyridine

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 942 ()

Background: and purpose: Phenazopyridine (PAP) is an over-the-counter drug widely used to provide symp-tomatic relief of bladder pain in conditions su......

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