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Monitoring Salivary Concentrations of Tedizolid and Linezolid Using Rats

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2023; 48 (4)

Background and ObjectiveTherapeutic drug monitoring (TDM) is an effective tool for the management of patients who are administered linezolid. The use ......

Nano Drug Delivery Strategies for an Oral Bioenhanced Quercetin Formulation

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2023; 48 (5)

Quercetin, a naturally occurring flavonoid, has been credited with a wide spectrum of therapeutic properties. However, the oral use of quercetin is li......

Comparative Pharmacokinetics of Commercially Available Cannabidiol Isolate, Broad-Spectrum, and Full-Spectrum Products

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2023; 48 (4)

Background and ObjectivesA wide variety of products containing cannabidiol (CBD) are available on the commercial market. One of the most common produc......

Plasma Protein Binding Refinement of the Extended Clearance Classification System: Subclasses for Predicting Hepatic Uptake or Renal Clearance for Classes 1B and 3B

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2023; 48 (1)

Background and Objectives The Extended Clearance Classification System (ECCS) was established to facilitate the timely anticipation of clearance rate ......

Relationship Between Serum Ustekinumab Trough Concentration and Clinical and Biochemical Disease Activity: A Real-World Study in Adult Patients with Crohn's Disease

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2023; 48 (3)

Background and ObjectivesThe role of therapeutic drug monitoring for ustekinumab in the treatment of Crohn's disease has not been defined. This study ......

First-in-Human Study of the Safety, Pharmacokinetics, and Pharmacodynamics of MHV370, a Dual Inhibitor of Toll-Like Receptors 7 and 8, in Healthy Adults

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2023; 48 (5)

Background and ObjectiveMHV370, a dual antagonist of human Toll-like receptors (TLR) 7 and 8, suppresses cytokines and interferon-stimulated genes in ......

Neurotherapeutic Effects of Quercetin and Its Metabolite Compounds on Cognitive Impairment and Parkinson's Disease: An In Silico Study

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2023; 48 (2)

Background and Objective Little is known about the metabolomic profile of quercetin and its biological effects. This study aimed to determine the biol......

Population Pharmacokinetic Model for Unbound Concentrations of Daptomycin in Patients with MRSA Including Patients Undergoing Hemodialysis

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2023; 48 (2)

Background and ObjectiveUnbound daptomycin concentrations are responsible for pharmacologically beneficial and adverse effects, although most previous......

Pharmacokinetics, Mass Balance and Metabolism of [14C]HSK21542, a Novel Kappa Opioid Receptor Agonist, in Humans

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2023; 48 (6)

Background and Objective HSK21542, a synthetic short-chain polypeptide, is a selective peripheral kappa opioid receptor (KOR) agonist. In this single-......

Dried Blood Spots-A Platform for Therapeutic Drug Monitoring (TDM) and Drug/Disease Response Monitoring (DRM)

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2023; 48 (5)

This review provides an overview on the current applications of dried blood spots (DBS) as matrices for therapeutic drug (TDM) and drug or disease res......

mRNA-Based Nanomedicine: A New Strategy for Treating Infectious Diseases and Beyond

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2023; 48 (5)

Messenger RNA (mRNA) has emerged as a new therapeutic agent for the prevention and treatment of a wide range of diseases. The recent achievement of th......

Pharmacokinetics of Long-Acting Methylphenidate: Formulation Differences, Bioequivalence, Interchangeability

期刊: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2023; ()

Background and ObjectiveAttention deficit hyperactivity disorder is one of the most common neuropsychiatric conditions in children, and methylphenidat......

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