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Inhibition of P2X4 and P2X7 receptors improves histological and behavioral outcomes after experimental traumatic brain injury in rats

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 26 (2)

Release of large amounts of adenosine triphosphate (ATP), a gliotransmitter, into the extracellular space by traumatic brain injury (TBI) is considere......

Resveratrol-mediated activation of SIRT1 inhibits the PERK-eIF2α-ATF4 pathway and mitigates bupivacaine-induced neurotoxicity in PC12 cells

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 26 (3)

Endoplasmic reticulum (ER) stress and apoptosis play significant roles in the development of neurotoxicity caused by bupivacaine (BUP). By activating ......

A giant, rapidly growing intra-abdominal desmoid tumor of mesenteric origin in an adolescent male: A case report and literature review

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 26 (4)

A desmoid tumor is a fibroblastic proliferation of mesenchymal origin, which has no metastasizing potential but is locally aggressive. Although treatm......

Protective effect of leukemia inhibitory factor on the retinal injury induced by acute ocular hypertension in rats

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 25 (1)

Glaucoma is one of the leading causes of irreversible blindness worldwide. As such, neuroprotective therapy is essential for the treatment of this dis......

Effect of a combination of Atractylodes macrocephala extract with strychnine on the TLR4/NF-?B/NLRP3 pathway in MH7A cells

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 25 (2)

Rheumatoid arthritis (RA) is now widely recognized as a chronic systemic inflammatory autoimmune disease characterized by swelling, pain and stiffness......

Esketamine for treatment-resistant depression: A review of clinical evidence (Review)

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 25 (3)

Treatment-resistant depression (TRD) is a challenge for psychiatrists, even after more than seven decades since the first antidepressants were used in......

Long-term prognosis and comprehensive endoscopic treatment strategy for esophageal cancer, including salvage endoscopic treatment after chemoradiation therapy

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 25 (3)

Endoscopic submucosal dissection (ESD) is the first treatment option for superficial squamous cell carcinoma of the esophagus (SSCE). Salvage endoscop......

DAB2 promotes pulmonary fibrosis and may act as an intermediate between IGF-1R and PI3K/AKT signaling pathways

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 25 (4)

Idiopathic pulmonary fibrosis (IPF) is a heterogeneous lung disease associated with high mortality. Disabled-2 (DAB2), an adapter protein, regulates c......

Diffuse gastric polyposis in a young patient with a giant retroperitoneal mass: A case report

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 25 (5)

Familial adenomatous polyposis (FAP) is characterized by hundreds of colonic adenomatous polyps and extraintestinal manifestations beginning in adoles......

Diosgenin alleviates the inflammatory damage and insulin resistance in high glucose-induced podocyte cells via the AMPK/SIRT1/NF-κB signaling pathway

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 25 (6)

Diabetic nephropathy (DN) is the predominant cause of end-stage renal disease globally. Diosgenin (DSG) has been reported to play a protective role in......

ZBTB16 eases lipopolysaccharide-elicited inflammation, apoptosis and degradation of extracellular matrix in chondrocytes during osteoarthritis by suppressing GRK2 transcription

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 25 (6)

Osteoarthritis (OA) is a chronic degenerative disease of the bone that is a major contributor of disability in the elderly population. Zinc finger and......

COVID-19 association with multidrug-resistant bacteria superinfections: Lessons for future challenges

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 25 (6)

The future waves of COVID 19 infections will continue to raise serious problems in patients with severe forms of the disease. Bacterial infections ass......

iRHOM2 regulates inflammation and endothelial barrier permeability via CX3CL1

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 26 (1)

Acute lung injury (ALI) is associated with increased lung inflammation and lung permeability. The present study aimed to determine the role of inactiv......

Expression and significance of cyclin D1, cyclin-dependent kinase 4 and cyclin-dependent kinase inhibitor P27 in patients with non-neoplastic epithelial disorders of the vulva

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 26 (1)

Non-neoplastic epithelial disorders of the vulva (NNEDV) are prevalent and refractory gynecological diseases. However, the underlying pathogenesis of ......

Physcion prevents induction of optic nerve injury in rats via inhibition of the JAK2/STAT3 pathway

期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023; 26 (2)

Optic nerve injury is a type of neurodegenerative disease. Physcion is an anthraquinone that exerts a protective role against various diseases. Howeve......

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