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The testis-, epididymis-, or seminal vesicle-enriched genes Aldoart2, Serpina16, Aoc1l3, and Pate14 are not essential for male fertility in mice

期刊: EXPERIMENTAL ANIMALS, 2023; 72 (3)

Spermatozoa released from the testis acquire fertilizing ability by translocating thorough the epididymis. Further, accessory gland secretions ejacula......

Transmembrane p24 trafficking protein 10 (TMED10) inhibits mitochondrial damage and protects neurons in ischemic stroke via the c-Jun N-terminal kinase (JNK) signaling pathway

期刊: EXPERIMENTAL ANIMALS, 2023; 72 (2)

Stroke, a type of acute cerebrovascular disease, is a global disease with high mortality. Neuronal ischemia and hypoxia are closely related to occurre......

Establishment of a human microbiome- and immune system-reconstituted dual-humanized mouse model

期刊: EXPERIMENTAL ANIMALS, 2023; 72 (3)

Humanized mice are widely used to study the human immune system in vivo and investigate therapeutic targets for various human diseases. Immunodeficien......

Canine bone marrow peri-adipocyte cells could therapeutically benefit acute spinal cord injury through migration and secretion of hepatocyte growth factor to inflammatory milieu

期刊: EXPERIMENTAL ANIMALS, 2023; 72 (1)

Spinal cord injury (SCI) is a common neurological disorder in dogs. A secondary injury that occurs in the acute phase causes expansion of inflammation......

A novel abdominal aortic aneurysm model produced by periarterial application of hydrochloric acid

期刊: EXPERIMENTAL ANIMALS, 2023; 72 (1)

Previous abdominal aortic aneurysm (AAA) animal modeling methodologies were either expensive or complicated. Here, we developed a novel AAA model whic......

Differences in susceptibility to ADR nephropathy among C57BL/6 substrains

期刊: EXPERIMENTAL ANIMALS, 2023; 72 (4)

Adriamycin (ADR) nephropathy is the most widely used nephropathy model to study the pathophysiological mechanisms of chronic kidney disease (CKD) in m......

Dynamics and observations of long-term orthodontic tooth movement and subsequent relapse in C57BL/6 mice

期刊: EXPERIMENTAL ANIMALS, 2023; 72 (1)

The risk of relapse associated with orthodontic treatment is a major problem. Despite extensive research and discussion regarding the risk of orthodon......

A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation

期刊: EXPERIMENTAL ANIMALS, 2023; 72 (1)

Aging is one of the greatest risk factors for postoperative cognitive dysfunction (POCD), also known as perioperative neurocognitive disorder (PND). A......

Positional cloning of rat mutant genes reveals new functions of these genes

期刊: EXPERIMENTAL ANIMALS, 2023; 72 (1)

The laboratory rat (Rattus norvegicus) is a key model organism for biomedical research. Rats can be subjected to strict genetic and environmental cont......

Comparison of protective effects of hesperetin and pectolinarigenin on high-fat diet-induced hyperlipidemia and hepatic steatosis in Golden Syrian hamsters

期刊: EXPERIMENTAL ANIMALS, 2023; 72 (1)

A comparative study was conducted to determine whether hesperetin and pectolinarigenin could lower total cholesterol (TC), triglycerides (TG), low-den......

SRY-box transcription factor 9 modulates Miller cell gliosis in diabetic retinopathy by upregulating TXNIP transcription

期刊: EXPERIMENTAL ANIMALS, 2023; 72 (3)

Diabetic retinopathy (DR), a common complication of diabetes, involves excessive proliferation and inflammation of Muller cells and ultimately leads t......

Neuroprotective effects of betanin in mice with cerebral ischemia-reperfusion injury

期刊: EXPERIMENTAL ANIMALS, 2023; 72 (3)

Cerebral ischemia reperfusion (IR) injury as found in stroke is a complex and heterogeneous disorder and closely related to disability and death. Toda......

Evaluation of different rat models intrauterine adhesion models and improvement of the technique for their establishment

期刊: EXPERIMENTAL ANIMALS, 2023; 72 (2)

Intrauterine adhesion (IUA), a leading cause of uterine infertility, is characterized by endometrial fibrosis. Implementing an appropriate animal mode......

The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway

期刊: EXPERIMENTAL ANIMALS, 2023; 72 (1)

Although hair loss is not a horrible disease, it sometimes reduces the patients' quality of life (QOL) and increases their mental stress. Currently, t......

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