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Resistin stimulates PC-3 prostate cancer cell growth through stimulation of SOCS3 and SOCS5 genes

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (20)

Resistin and suppressors of cytokine signaling (SOCSs) have been reported to regulate prostate cancer (PCa) cell proliferation and survival, respectiv......

Synthesis of glycine from 4-hydroxyproline in tissues of neonatal pigs with intrauterine growth restriction

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (17)

This study tested the hypothesis that the synthesis of glycine from 4-hydroxyproline (an abundant amino acid in milk and neonatal blood) was impaired ......

Visceral fat sympathectomy ameliorates systemic and local stress response related to chronic sleep restriction

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (23)

Disturbance of sleep homeostasis encompasses health issues, including metabolic disorders like obesity, diabetes, and augmented stress vulnerability. ......

Single-nucleotide polymorphisms of TLR4 and GAS7 linked to primary open-angle glaucoma among patients of Shenyang, China

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (23)

The potential for adverse outcomes and classifications of glaucoma differ among race, country, gender, and family medical history. Nearly, 50 represen......

Transmembrane serine protease 2 cleaves nidogen 1 and inhibits extrahepatic liver cancer cell migration and invasion

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (2)

We aimed to confirm whether transmembrane serine protease 2 (TMPRSS2) regulates nidogen 1 (NID1) expression in extracellular vesicles (EVs) and metast......

Imbalance of follicular regulatory T (Tfr) cells/follicular helper T (Tfh) cells in adult patients with primary immune thrombocytopenia

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (11)

This study is to investigate the role of follicular regulatory T (Tfr) cells/follicular helper T (Tfh) cells imbalance in adult patients with primary ......

Synergetic enrichment of aggrecan in nucleus pulposus cells by scAAV6-shRNA-mediated knockdown of aggrecanase-1 and aggrecanase-2

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (13)

Degenerative disk disease (DDD) that aggravates structural deterioration of intervertebral disks (IVDs) can be accompanied by painful inflammation and......

The inducible prostaglandin E synthase (mPGES-1) in neuroinflammatory disorders

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (9)

The cyclooxygenase (COX)/prostaglandin E2 (PGE(2)) signaling pathway has emerged as a critical target for anti-inflammatory therapeutic development in......

TGFβ1 induces CXCL1 to promote stemness features in lung cancer

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (23)

Chemokines critically orchestrate the tumorigenesis, metastasis, and stemness features of cancer cells that lead to poor outcomes. High plasma levels ......

Link between m6A modification and infiltration characterization of tumor microenvironment in lung adenocarcinoma

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (23)

N6-methyladenosine (m6A) RNA methylation plays a pivotal role in immune responses and the onset and advancement of cancer. Nonetheless, the precise im......

Environmentally persistent free radicals enhance SARS-CoV-2 replication in respiratory epithelium

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (3)

Epidemiological evidence links lower air quality with increased incidence and severity of COVID-19; however, mechanistic data have yet to be published......

Plasma Galectin-3 and H-FABP correlate with poor physical performance in patients with congestive heart failure

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (6)

Heart failure (HF) is often associated with compromised physical capacity in patients. However, it is unclear if established HF markers correlate with......

N-acetylcysteine improves autism-like behavior by recovering autophagic deficiency and decreasing Notch-1/Hes-1 pathway activity

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (11)

N-acetylcysteine (NAC) has been reported to improve social interaction behavior, irritability, self-injury, and anxiety-like behavior in autism. Howev......

Participation of ASK-1 in the cardiomyocyte-protective role of mechanical ventilation in a rat model of myocardial infarction

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (18)

Non-invasive positive-pressure ventilation (NIPPV) has been demonstrated to exhibit a cardioprotective function in a rat model of myocardial infarctio......

Respiratory viral infection and resolution of inflammation: Roles for specialized pro-resolving mediators

期刊: EXPERIMENTAL BIOLOGY AND MEDICINE, 2023; 248 (19)

Respiratory viral infections with influenza A virus (IAV) or respiratory syncytial virus (RSV) pose a significant threat to public health due to exces......

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