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Alveolar epithelial cell growth hormone releasing hormone receptor in alveolar epithelial inflammation

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

Purpose: Growth hormone-releasing hormone (GHRH) is a 44-amino acid peptide that regulates growth hormone (GH) secretion. We hypothesized that GHRH re......

Cigarette smoke extract-induced inflammatory response via inhibition of the TFEB-mediated autophagy in NR8383 cells

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

Objective: Chronic pulmonary inflammation caused by long-term smoking is the core pathology of COPD. Alveolar macrophages (AMs) are involved in the pu......

Effect of mechanical ventilation under intubation on respiratory tract change of bacterial count and alteration of bacterial flora

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

Background: The most common 'second strike' in mechanically ventilated patients is a pulmonary infection caused by the ease with which bacteria can in......

Stevioside attenuates bleomycin-induced pulmonary fibrosis by activating the Nrf2 pathway and inhibiting the NF-κB and TGF-β1/Smad2/3 pathways

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

Objective: This study aimed to investigate the effects of stevioside (STE) on pulmonary fibrosis (PF) and the potential mechanisms. Methods: In this s......

METTL14 knockdown inhibits the pyroptosis in the sepsis-induced acute lung injury through regulating the m6A modification of NLRP3

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

Background: Sepsis has become one of the main factors inducing the development of acute lung injury (ALI) in clinical practice. Currently, inhibiting ......

HIF and ER stress are involved in TGFβ1-mediated wound closure of alveolar epithelial cells

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

Purpose: Alveolar epithelium dysfunction is associated with a very large spectrum of disease and an abnormal repair capacity of the airway epithelium ......

p14ARF ameliorates inflammation and airway remodeling in nitric acid aerosol inhalation-induced bronchiolitis obliterans

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

BackgroundTo investigate the protective effect of p14ARF in a nitric acid (NA) aerosol inhalation-induced bronchiolitis obliterans (BO) mouse model an......

Ultrastructural analysis of the intracellular surfactant in lungs of healthy and ovalbumin sensitized and challenged Brown Norway rats

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

Introduction: In human and experimentally induced asthma, a dysfunction of the intra-alveolar-surface active agent (surfactant) has been demonstrated.......

Melatonin attenuates lung ischemia-reperfusion injury through SIRT3 signaling-dependent mitophagy in type 2 diabetic rats

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

Background: Lung ischemia-reperfusion injury (LIRI) remains the major cause of primary lung dysfunction after lung transplantation. Diabetes mellitus ......

Chronic exposure to ampicillin alters lung microbial composition in laboratory rat

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

S Purpose High-throughput sequencing technologies have revealed that the lungs contain a variety of low biomass microbiota associated with various lun......

House dust mite-induced endoplasmic reticulum stress mediates MUC5AC hypersecretion via TBK1 in airway epithelium

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

Purpose: Endoplasmic reticulum (ER) stress regulates mucus hypersecretion, and may activate downstream factors via TBK1 signaling to induce gene expre......

Comparison of hypoxia-induced pulmonary hypertension rat models caused by different hypoxia protocols

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

Background and aim: Pulmonary hypertension (PH) is a serious and even fatal disorder with limited treatment strategies. The hypoxia-induced pulmonary ......

Rapamycin attenuates pyroptosis by suppressing mTOR phosphorylation and promoting autophagy in LPS-induced bronchopulmonary dysplasia

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

Purpose/Aim Bronchopulmonary dysplasia (BPD) is associated with poor survival in preterm infants. Intrauterine infection can aggravate the degree of o......

Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

PurposeChronic obstructive pulmonary disease (COPD) patients experience hypoxemia and lung tissue hypoxia, causing vasoconstriction, and at its most s......

The multiphasic TNF-α-induced compromise of Calu-3 airway epithelial barrier function

期刊: EXPERIMENTAL LUNG RESEARCH, 2023; 49 (1)

Purpose: Airway epithelial barrier leak and the involvement of proinflammatory cytokines play a key role in a variety of diseases. This study evaluate......

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