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Comet-FISH analysis of urothelial cells. A screening opportunity for bladder cancer?

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; 23 (8)

Introduction: Bladder cancer (BCa) is the most frequent cancer of the urinary tract, with more than 500,000 reported cases and nearly 200,000 related ......

Lost in translation: the pitfalls of Ensembl gene annotations between human genome assemblies and their impact on diagnostics

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; ()

BackgroundGene models based on GRCh37 human genome assembly are preferred by many international projects over other updated assemblies (GRCh38 and T2T......

Investigation of the clinicopathological and prognostic role of circMTO1 in multiple cancers

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; 23 (2)

ObjectiveTo observe the prognostic value of circular RNA mitochondrial tRNA translation optimization 1 (circMTO1) in human tumors.MethodsWe searched m......

Noncoding RNAs as a potential biomarker for the prognosis of bladder cancer: a systematic review and meta-analysis

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; ()

ObjectiveThe relationship between noncoding RNAs and the prognosis of bladder cancer (BC) is still controversial. The purpose of this study is to eval......

Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; ()

IntroductionThe non-invasive identification of liver fibrosis related to Non-Alcoholic Fatty Liver Disease is crucial for risk-stratification of patie......

Discovery of potential biomarkers for osteoporosis diagnosis by individual omics and multi-omics technologies

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; 23 (6)

IntroductionGlobal aging has made osteoporosis an increasingly serious public health problem. Osteoporotic fractures seriously affect the quality of l......

Promotor methylation in ocular surface squamous neoplasia development: epigenetics implications in molecular diagnosis

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; ()

IntroductionCancer is heavily influenced by epigenetic mechanisms that include DNA methylation, histone modifications, and non-coding RNA. A considera......

The diagnostic and prognostic value of tsRNAs in gastric cancers: a systematic review and meta-analysis

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; 23 (11)

Background: Gastric cancer (GC) is one of the most common types of cancer worldwide. Recent studies have shown that tsRNAs play important roles in GC ......

Implementing Individualized quality control plans and managing risk at the point-of-care for molecular diagnostics

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; ()

IntroductionFaster turnaround times can lead to rapid patient treatment. Implementing a point-of-care (POC) molecular COVID-19 test requires careful p......

Cross-sectional risk models using quantitative fecal hemoglobin in colorectal cancer screening: a systematic review

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; 23 (12)

IntroductionFecal Immunochemical Testing (FIT) is a central tool in colorectal cancer (CRC) screening. To improve the selection of individuals for col......

MicroRNA dysregulation in schistosomiasis-induced hepatic fibrosis: a systematic review

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; 23 (3)

Background: MicroRNAs are involved in gene regulation in several common liver diseases and may play an essential role in activating hepatic stellate c......

Retrospective analysis of persistent HyperCKemia with or without muscle weakness in a case series from Greece highlights vast DMD variants' heterogeneity

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; 23 (11)

Background: Persistent hyperCKemia results from muscle dysfunction often attributed to genetic alterations of muscle-related genes, such as the dystro......

LncRNA NR2F1-AS1 as a potential biomarker for prognosis in cancer patients: meta and bioinformatics analysis

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; 23 (12)

Background: Previous studies have shown that the differential expression of lncRNA NR2F1-AS1 is closely related to the prognosis of cancer, but the co......

Highlighting and addressing barriers to widespread adaptation of HIV self-testing in the United States

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; 23 (3)

IntroductionHIV self-testing (HIVST), whereby an individual performs and interprets their own rapid screening test at home, is another tool to increas......

Updates on the profile of GenMark's ePlex blood culture identification fungal pathogen panel

期刊: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023; 23 (6)

IntroductionThe clinical and economical burdens of invasive fungal diseases (IFDs) remain substantial despite advances in diagnostics and therapeutics......

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