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An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2023; 27 (7)

IntroductionMultiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative condition affecting the central nervous system (CN......

The role of ubiquitination in microbial infection induced endothelial dysfunction: potential therapeutic targets for sepsis

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2023; 27 (9)

IntroductionThe ubiquitin system is an evolutionarily conserved and universal means of protein modification that regulates many essential cellular pro......

Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2023; 27 (12)

AimsDespite the promise of immunotherapy for gastric adenocarcinoma, resistance is common, necessitating the validation of new targets. Based on our p......

Bromodomain-containing protein 4 (BRD4): a key player in inflammatory bowel disease and potential to inspire epigenetic therapeutics

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2023; 27 (1)

Introduction: Inflammatory bowel diseases (IBDs) are debilitating chronic inflammatory disorders with increasing prevalence worldwide. Epigenetic regu......

Seizure-suppressor genes: can they help spearhead the discovery of novel therapeutic targets for epilepsy?

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2023; 27 (8)

IntroductionEpilepsies are disorders of neuronal excitability characterized by spontaneously recurrent focal and generalized seizures, some of which r......

Advances in molecular therapies for targeting pathophysiology in spinal cord injury

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2023; 27 (3)

IntroductionSpinal cord injury (SCI) affects 25,000-50,000 people around the world each year and there is no cure for SCI patients currently. The prim......

Focusing on oligomeric tau as a therapeutic target in Alzheimer's disease and other tauopathies

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2023; 27 (4-5)

IntroductionTau has commanded much attention as a potential therapeutic target in neurodegenerative diseases. Tau pathology is a hallmark of primary t......

Novel signatures of prostate cancer progression and therapeutic resistance

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2023; 27 (12)

IntroductionThe extensive heterogeneity of prostate cancer (PCa) and multilayered complexity of progression to castration-resistant prostate cancer (C......

Shedding light on emerging therapeutic targets for chordoma

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2023; 27 (8)

IntroductionDespite encouraging advances in radiation and surgical treatment, chordomas remain resistant to chemotherapy and local recurrence is commo......

Airway smooth muscle in contractility and remodeling of asthma: potential drug target mechanisms

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2023; 27 (1)

IntroductionAsthma is characterized by enhanced airway contractility and remodeling where airway smooth muscle (ASM) plays a key role, modulated by in......

Riboswitches as therapeutic targets: promise of a new era of antibiotics

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2023; ()

Introduction: The growth of antibiotic resistance among bacterial pathogens is an impending global threat that can only be averted through the develop......

Targeting GABA receptors with chalcone derivative compounds, what is the evidence?

期刊: EXPERT OPINION ON THERAPEUTIC TARGETS, 2023; 27 (12)

IntroductionIn medicinal chemistry, privileged structures have been frequently exploited as a successful template for drug discovery. Common simple sc......

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