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Twin research shows glycan changes are more susceptible to environmental factors than their carrier glycoproteins

期刊: GLYCOCONJUGATE JOURNAL, 2023; 40 (2)

Changes in protein glycosylation are clinically used as biomarkers. In the present study, we employed a twin cohort to investigate the contributions o......

Possible regulation of ganglioside GD3 synthase gene expression with DNA methylation in human glioma cells

期刊: GLYCOCONJUGATE JOURNAL, 2023; 40 (3)

Gangliosides are expressed in nervous systems and some neuroectoderm-derived tumors at high levels and play pivotal roles. However, mechanisms for the......

Plant lectins as versatile tools to fight coronavirus outbreaks

期刊: GLYCOCONJUGATE JOURNAL, 2023; 40 (1)

The S protein forming the homotrimeric spikes of pathogenic beta-coronaviruses, such as MERS-CoV, SARS-CoV and SARS-CoV-2, is a highly glycosylated pr......

Serum total carbohydrates, conjugated carbohydrates and total protein glycation index in diabetes mellitus

期刊: GLYCOCONJUGATE JOURNAL, 2023; 40 (3)

Background: Diabetes mellitus is defined according to fasting blood glucose and clinical signs. But, the markers of glycation have been used recently ......

Interactions between polysialic acid and dopamine-lead compounds as revealed by biochemical and in silico docking simulation analyses

期刊: GLYCOCONJUGATE JOURNAL, 2023; 40 (4)

Polysialic acid is an important glyco-epitope in vertebrate brains, while altered expressions of polySia and biosynthetic enzyme have been reported in......

The story of the Sda antigen and of its cognate enzyme B4GALNT2: What is new?

期刊: GLYCOCONJUGATE JOURNAL, 2023; 40 (1)

The structure Sia alpha 2,3(GalNAc beta 1,4)Gal- is the epitope of the Sd(a) antigen, which is expressed on the erythrocytes and secretions of the vas......

Alkali-labile gangliosides

期刊: GLYCOCONJUGATE JOURNAL, 2023; 40 (3)

The structure and properties of a group of gangliosides modified by mild alkaline treatment are discussed. We will present the occurrence and the stru......

Sialoadhesin (CD169/Siglec-1) is an extended molecule that escapes inhibitory cis-interactions and synergizes with other macrophage receptors to promote phagocytosis

期刊: GLYCOCONJUGATE JOURNAL, 2023; 40 (2)

Sialoadhesin (CD169/Siglec-1, Sn) is a macrophage receptor that interacts with sialic acids on both host cells and pathogens. It is a type 1 membrane ......

Interaction of sugar stabilised silver nanoparticles with Momordica charantia seed lectin, a type II ribosome inactivating protein

期刊: GLYCOCONJUGATE JOURNAL, 2023; 40 (2)

Sugar-stabilised nanomaterials have received a lot of attention in cancer therapy in recent years due to their pronounced application as specific targ......

Straightforward synthesis of the hexasaccharide repeating unit of the O-specific polysaccharide of Salmonella arizonae O62

期刊: GLYCOCONJUGATE JOURNAL, 2023; 40 (4)

A straightforward synthesis of the hexasaccharide repeating unit of the O-specific polysaccharide of Salmonella arizonae O62 was achieved in very good......

Vibrio-binding gangliosides in fish intestinal tracts

期刊: GLYCOCONJUGATE JOURNAL, 2023; 40 (3)

It has been clarified that pathogens bind to glycosphingolipid (GSL) receptors in mammals, but there have been very few reports on pathogen-binding GS......

Elevated concentrations of Neu5Ac and Neu5,9Ac2 in human plasma: potential biomarkers of cardiovascular disease

期刊: GLYCOCONJUGATE JOURNAL, 2023; 40 (6)

Cardiovascular disease (CVD) is a group of health conditions affecting the heart and vascular system with very high prevalence and mortality rates. Th......

Neuroimmunomodulatory properties of polysialic acid

期刊: GLYCOCONJUGATE JOURNAL, 2023; 40 (3)

Polymeric sialic acid (polysialic acid, polySia) is a remarkable posttranslational modification of only few select proteins. The major, and most promi......

Lysosomal sialidase NEU1, its intracellular properties, deficiency, and use as a therapeutic agent

期刊: GLYCOCONJUGATE JOURNAL, 2023; 40 (6)

Neuraminidase 1 (NEU1) is a lysosomal sialidase that cleaves terminal alpha-linked sialic acid residues from sialylglycans. NEU1 is biosynthesized in ......

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