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Kaempferol inhibits airway inflammation induced by allergic asthma through NOX4-Mediated autophagy

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

BackgroundKaempferol has important medicinal value in the treatment of asthma. However, its mechanism of action has not been fully understood and need......

Cysteine-rich 61(CYR61) alleviates cyclophosphamide-induced proliferation inhibition in ovarian granulosa cells via suppressing NLRP3/caspase1-mediated pyroptosis

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

BackgroundWe investigated the level of Cysteine-rich 61 (CYR61) in premature ovarian failure as well as its regulatory molecular mechanism in this stu......

Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

Arsenic is a prevalent environmental pollutant that targets the nervous system of living beings. Recent studies indicated that microglial injury could......

Rhamnazin ameliorates 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-evoked testicular toxicity by restoring biochemical, spermatogenic and histological profile in male albino rats

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) is a potential environmental toxin that has the ability to affect male reproductive tract. Rhamnazin is a n......

Integrative analysis of renal microRNA and mRNA to identify hub genes and pivotal pathways associated with cyclosporine-induced acute kidney injury in mice

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

Cyclosporine (CsA) is an immunosuppressive agent that often causes acute kidney injury (AKI) in children. The specific mechanisms underlying CsA-induc......

Neurologic disease produced by Rathayibacter toxicus-derived corynetoxins

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

Corynetoxins, members of the tunicamycin group of antibiotics, are produced by the bacterium, Rathayibacter toxicus. They cause a severe neurologic di......

Tricin attenuates diabetic retinopathy by inhibiting oxidative stress and angiogenesis through regulating Sestrin2/Nrf2 signaling

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

To explore the potential function of tricin in diabetic retinopathy (DR) and investigate whether Sestrin2 is closely involved in DR. A single intraper......

Tanshinone IIA inhibits ischemia-reperfusion-induced inflammation, ferroptosis and apoptosis through activation of the PI3K/Akt/mTOR pathway

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

Ischemia-reperfusion (I/R) is a common clinical process, and the lung is one of the most sensitive organs of I/R injury, which often leads to acute lu......

TLR4/MyD88/NF-κB signaling pathway involved in the protective effect of diacerein against lung fibrosis in rats

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

PurposePulmonary fibrosis (PF) is an inescapable problem. Diacerein, a chondro-protective drug, has antioxidant and anti-inflammatory effects. Its eff......

Environmental contaminants, endocrine disruption, and transgender: Can born that way in some cases be toxicologically real?

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

Gender is viewed by many as strictly binary based on a collection of body traits typical of a female or male phenotype, presence of a genotype that in......

Signature of miR-21 and MEG-2 and their correlation with TGF-β signaling in breast cancer

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

Breast cancer is highly prevalent and considered the main challenge to public health among females in Egypt as in other countries. MicroRNA-21 (miR-21......

Hydroxychloroquine ameliorates dasatinib-induced liver injury via decrease in hepatic lymphocytes infiltration

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

Dasatinib is an effective treatment for chronic myeloid leukemia. However, cases of idiosyncratic hepatotoxicity were reported. This study was conduct......

Follow-up of patients with a 5-year survival after paraquat poisoning using computed tomography images and spirometry

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

ObjectivesThe study aimed to examine long-term survival of patients with acute paraquat poisoning using computed tomography (CT) images and spirometry......

Anlotinib induces apoptosis and second growth/mitosis phase block in cisplatin-resistant ovarian cancer cells via the aurora kinase A/p53 pathway

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

BackgroundCisplatin (DDP) resistance in ovarian cancer (OC) patients usually leads to treatment failure and increased mortality. Anlotinib has been sh......

A mechanistic investigation about hepatoxic effects of borneol using zebrafish

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2023; 42 ()

Except for clinical value, borneol is routinely used in food and cosmetics with seldom safety evaluation. To investigate its hepatoxicity, we exposed ......

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