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Dual functional pullulan-based spray-dried microparticles for controlled pulmonary drug delivery

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 641 ()

Two main challenges are associated with current spray-dried microparticles for inhalation, including the enhancement of aerosolization performance of ......

AI-based analysis of in-line process endoscope images for real-time particle size measurement in a continuous pharmaceutical milling process

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 641 ()

This paper presents a case study on the first in-line application of AI-based image analysis for real-time pharmaceutical particle size measurement in......

Preformulation study for the selection of a suitable polymer for the development of ellagic acid-based solid dispersion using hot-melt extrusion

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 641 ()

Ellagic acid is one of the most studied polyphenolic compounds due to its numerous promising therapeutic properties. However, this therapeutic potenti......

3D screen printing technology enables fabrication of oral drug dosage forms with freely tailorable release profiles

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 642 ()

3D printing offers new opportunities to customize oral dosage forms of pharmaceuticals for different patient populations, improving patient safety, ca......

Inhaled lipid nanocarriers for pulmonary delivery of glucocorticoids: Previous strategies, recent advances and key factors description

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 642 ()

In view of the strong anti-inflammatory activity of glucocorticoids (GC) they are used in the treatment of almost all inflammatory lung diseases. In p......

Tannic acid-based sustained-release system for protein drugs

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 643 ()

In recent years, protein drug development has gained momentum, and simple and facile controlled-release systems without loss of activity are required.......

Novel liposomal formulations for protection and delivery of levodopa: Structure-properties correlation

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 643 ()

Liposomes are promising drug carriers for a wide range of central nervous system disorders, such as Parkinson's disease (PD), since they can protect a......

Mechanically promoted lipid-based filaments via composition tuning for extrusion-based 3D-printing

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 643 ()

Lipid excipients are favorable materials in pharmaceutical formulations owing to their natural, biodegradable, low-toxic and solubility/permeability e......

Enhanced powder dispersion of dual-excipient spray-dried powder formulations of a monoclonal antibody and its fragment for local treatment of severe asthma

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 644 ()

The advent of biologics has brought renewed hope for patients with severe asthma, a condition notorious for being hampered by poor response to convent......

Physicochemical considerations in the formulation development of silicone elastomer vaginal rings releasing 5-nitroimidazole drugs for the treatment of bacterial vaginosis

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 644 ()

Bacterial vaginosis (BV) is a common dysbiosis of the human vaginal microbiota characterized by depletion of hydrogen peroxide and lactic acid-produci......

Development of mabuterol transdermal patch: Molecular mechanism study of ion-pair improving patch stability

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 644 ()

This paper aimed to prepare a Mabuterol (MAB) patch for treating asthma by ion-pair strategy to overcome the drug's thermal instability and elucidate ......

Enhancing the properties of electrospun polyvinyl Alcohol/Oxidized sodium alginate nanofibers with fluorescence carbon Dots: Preparation and characterization

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 644 ()

The objective of this study was to develop fluorescence nanofibrous polyvinyl alcohol/oxidized sodium alginate (PVA-OSA) incorporated with carbon dots......

Nose-to-brain delivery of 18β-Glycyrrhetinic acid using optimized lipid nanocapsules: A novel alternative treatment for Alzheimer's disease

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 645 ()

Alzheimer's disease (AD) is a neurodegenerative disorder and the most relevant form of dementia affecting people worldwide. AD was reported to be asso......

Computer numerical control (CNC) carving as an on-demand point-of-care manufacturing of solid dosage form: A digital alternative method for 3D printing

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 645 ()

Computer numerical control (CNC) carving is a widely used method of industrial subtractive manufacturing of wood, plastics, and metal products. Howeve......

ROS/pH dual-sensitive emodin-chlorambucil co-loaded micelles enhance anti-tumor effect through combining oxidative damage and chemotherapy

期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023; 647 ()

The high level of reactive oxygen species (ROS) at the tumor site has been widely used in the tumor targeted delivery. However, the ROS stimulus-respo......

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