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3D bioprinting of emulating homeostasis regulation for regenerative medicine applications

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 353 ()

Homeostasis is the most fundamental mechanism of physiological processes, occurring simultaneously as the production and outcomes of pathological proc......

The mechanisms of anti-PEG immune response are different in the spleen and the lymph nodes

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 353 ()

Polyethylene glycol (PEG) is a common ingredient in nanomedicines and pharmaceuticals. Recent studies show that approximately 20-70% of humans have an......

Elastin-like polypeptide-based micelles as a promising platform in nanomedicine

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 353 ()

New and improved nanomaterials are constantly being developed for biomedical purposes. Nanomaterials based on elastin-like polypeptides (ELPs) have in......

Frustoconical porous microneedle for electroosmotic transdermal drug delivery

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 354 ()

A truncated cone-shaped porous microneedle (PMN) made of poly-glycidyl methacrylate was studied as a minimally invasive tool for transdermal drug deli......

Nanotechnology for next-generation cancer immunotherapy: State of the art and future perspectives

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 356 ()

Over the past decade, immunotherapy aiming to activate an effective antitumor immune response has ushered in a new era of cancer treatment. However, t......

Spleen-selective co-delivery of mRNA and TLR4 agonist-loaded LNPs for synergistic immunostimulation and Th1 immune responses

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 357 ()

Spleen is an ideal site for initiating and amplifying antigen-specific immune response. However, spleen-selective antigen delivery has limited tumor t......

A chemiluminescent reporter assisted by in-situ neutrophils for imaging O2 •- at inflammatory sites

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 358 ()

Precisely reporting the inflammatory microenvironment, which can provide important basis for disease diagnosis and progression determination, is alway......

Primaquine and chloroquine nano-sized solid dispersion-loaded dissolving microarray patches for the improved treatment of malaria caused by Plasmodium vivax

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 361 ()

Malaria is a global parasitic infection that leads to substantial illness and death. The most commonly-used drugs for treatment of malaria vivax are p......

Intravitreal implants manufactured by supercritical foaming for treating retinal diseases

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 362 ()

Chronic retinal diseases, such as age-related macular degeneration (AMD), are a major cause of global visual impairment. However, current treatment me......

Engineered mesenchymal stem cell-derived extracellular vesicles constitute a versatile platform for targeted drug delivery

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 363 ()

Extracellular vesicles (EVs) are promising therapeutic carriers owing to their ideal size range and intrinsic biocompatibility. However, limited targe......

Electrospun fibers for the treatment of skin diseases

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 363 ()

Skin diseases are among the most common diseases in the global population and with the growth of the aging population, they represent an increasing bu......

Enhancing tumor immunotherapy via photodynamic therapy with a cascade reaction of reactive oxygen species and sustaining nutrient supply

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 364 ()

Photo-immunotherapy is a promising strategy for the treatment of malignancies; however, its efficacy is often limited by the low tumor immunogenicity ......

Astrocytes and microglia-targeted Danshensu liposomes enhance the therapeutic effects on cerebral ischemia-reperfusion injury

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 364 ()

Cerebral ischemia-reperfusion injury (CI/RI) is the main cause of disability and death in stroke without satisfactory therapeutic effect. Inflammation......

Comprehensive evaluation of biopolymer immune implants for peritoneal metastasis carcinoma therapy

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 353 ()

Immunotherapy has been widely used in the treatment of advanced stage cancers with spreading metastases, while the fully activation of immune system o......

Triggered release from thermosensitive liposomes improves tumor targeting of vinorelbine

期刊: JOURNAL OF CONTROLLED RELEASE, 2023; 354 ()

Triggered drug delivery strategies have been shown to enhance drug accumulation at target diseased sites in comparison to administration of free drug.......

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