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The activity of cytokines in dental pulp

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (9)

Background After binding to their corresponding receptors, cytokines mediate a variety of biological activities. However, the activity of cytokines in......

JIF:3.0

Characterization of the evolution trajectory and immune profiling of new histologic patterns in lung adenocarcinoma

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (11)

In lung adenocarcinoma (LUAD), the appearance of morphologically diverse tumor regions, termed histological patterns, is closely associated with disea......

JIF:3.0

Design of a new cell penetrating peptide for DNA, siRNA and mRNA delivery

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (3)

Background Delivery systems, including peptide-based ones, that destabilize endosomes in a pH-dependent manner are increasingly used to deliver cargoe......

JIF:3.0

Brain and visceral gene editing of mucopolysaccharidosis I mice by nasal delivery of the CRISPR/Cas9 system

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (4)

Background Mucopolysaccharidosis type I (MPS I) is an inherited disease caused by deficiency of the enzyme alpha-l-iduronidase (IDUA). MPS I affects s......

JIF:3.0

CDK14/beta-catenin/TCF4/miR-26b positive feedback regulation modulating pancreatic cancer cell phenotypes in vitro and tumor growth in mice model in vivo

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (2)

Introduction: Chemotherapy and radiotherapy have been reported to be basically ineffective for pancreatic ductal adenocarcinoma patients; thus, gene t......

JIF:3.0

LINC01291 promotes hepatocellular carcinoma development by targeting the miR-186-5p/OXSR1 axis

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (2)

Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Recent studies have demonstrated that lncRNAs play an important......

JIF:3.0

The role of ABCB1 gene polymorphisms in steroid-resistant nephrotic syndrome: Evidence from a meta-analysis of steroid-receiving patients

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (7)

Previous studies in nephrotic syndrome have shown that three common variants in the ABCB1 gene, including rs1128503, rs2032582, and rs1045642, change ......

JIF:3.0

TaqI polymorphism T/t genotypes at the vitamin D receptor gene (VDR) are associated with increased serum vitamin D levels in mild and moderate psoriasis vulgaris: A pilot study

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (10)

Background Several types of polymorphisms in vitamin D receptor (VDR) have been found in psoriasis. Aim This study looked at the role of the TaqI poly......

JIF:3.0

The CHST11 gene is linked to lung cancer and pulmonary fibrosis

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (12)

Background The abnormal modification of chondroitin sulfate is one of the leading causes of disease, including cancer progression. During chondroitin ......

JIF:3.0

A novel variant of C12orf4 linked to autosomal recessive intellectual disability type 66 with phenotype expansion

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (4)

Background Intellectual disability (ID) is a hallmark of many rare disorders that are highly heterogeneous and complex. A large number of specific gen......

JIF:3.0

Association between polymorphisms of ABCB1 and prognosis in esophageal squamous cell carcinoma patients treated with taxane

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (7)

Background In China, most esophageal cancer patients are squamous cell carcinomas and are treated with taxane-containing regimens; however, few studie......

JIF:3.0

Marked increase in tumor transfection with a truncated branched polymer

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (1)

Background We previously determined that polyplexes formed by linear H2K peptides were more effective in transfecting tumors in vivo than polyplexes f......

JIF:3.0

Circular RNA ITCH attenuates the progression of nasopharyngeal carcinoma by inducing PTEN upregulation via miR-214

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (1)

Background Circular RNA itchy E3 ubiquitin protein ligase (circ-ITCH) has previously been reported to play a key role in carcinogenesis. Nevertheless,......

JIF:3.0

Homozygous missense variant in POPDC3 causes recessive limb-girdle muscular dystrophy type 26

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (4)

Background Limb-girdle muscular dystrophy (LGMD) comprises a heterogeneous group of diseases, affecting different muscles, predominantly skeletal musc......

JIF:3.0

CSRP3, p.Arg122*, is responsible for hypertrophic cardiomyopathy in a Chinese family

期刊: JOURNAL OF GENE MEDICINE, 2022; 24 (1)

Background Hypertrophic cardiomyopathy (HCM) is a hereditary disease manifested by a thickened ventricular wall. Cysteine and glycine-rich protein 3 (......

JIF:3.0

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