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Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice

期刊: JOURNAL OF NEUROSCIENCE METHODS, 2023; 390 ()

Background: Primary neuronal cultures enable cell-biological studies of Alzheimer's disease (AD), albeit typically non-neuron-specific. The first cort......

Comparison of automated video tracking systems in the open field test: ANY-Maze versus EthoVision XT

期刊: JOURNAL OF NEUROSCIENCE METHODS, 2023; 397 ()

Background: ANY-Maze and EthoVision XT are two commonly used automated animal tracking systems employed to produce reliable and consistent results in ......

Prediction of gender from longitudinal MRI data via deep learning on adolescent data reveals unique patterns associated with brain structure and change over a two-year period

期刊: JOURNAL OF NEUROSCIENCE METHODS, 2023; 384 ()

Deep learning algorithms for predicting neuroimaging data have shown considerable promise in various applications. Prior work has demonstrated that de......

Risky decision-taking task: A novel paradigm to assess the risk-taking behaviour in rats predisposed to early-life stress

期刊: JOURNAL OF NEUROSCIENCE METHODS, 2023; 392 ()

One of the characteristic features of adolescence is risk-taking behavioural traits. Uncontrolled risk-taking without proper assessment may have harmf......

Dedicated odor-taste stimulation design for fMRI flavor studies

期刊: JOURNAL OF NEUROSCIENCE METHODS, 2023; 393 ()

Background: Flavor is a mental representation that results from the brain's integration of at least odor and taste, and fMRI can highlight brain-relat......

High-frequency ultrasound-guided intrathecal injections in a young mouse model: Targeting the central nervous system in drug delivery

期刊: JOURNAL OF NEUROSCIENCE METHODS, 2023; 386 ()

Background: Intrathecal injections provide important access to the central nervous system for delivery of anes-thetic, analgesic or chemotherapeutic d......

EEG-based source localization with enhanced virtual aperture using second order statistics

期刊: JOURNAL OF NEUROSCIENCE METHODS, 2023; 389 ()

For the past few decades source localization, based on EEG modality, has been a very active area of research. EEG signal provides temporal resolution ......

Measurement of the N170 during facial neuromuscular electrical stimulation (fNMES)

期刊: JOURNAL OF NEUROSCIENCE METHODS, 2023; 393 ()

Background: Studies on facial feedback effects typically employ props or posed facial expressions, which often lack temporal precision and muscle spec......

Methodical advances in reproducibility research: A proof of concept qualitative comparative analysis of reproducing animal data in humans

期刊: JOURNAL OF NEUROSCIENCE METHODS, 2023; 397 ()

Background: While the term reproducibility crisis mainly reflects reproducibility of experiments between laboratories, reproducibility between species......

Substantially improved gene transfer to interneurons with second-generation glutamate receptor-targeted DART-AAV vectors

期刊: JOURNAL OF NEUROSCIENCE METHODS, 2023; 399 ()

Background: Adeno-associated viral vectors (AAVs) are a widely used gene transfer platform in neuroscience. Although naturally AAV serotypes can have ......

The UK Reproducibility Network: A progress report

期刊: JOURNAL OF NEUROSCIENCE METHODS, 2023; 397 ()

There is growing awareness that the ways in which academic research is conducted could be improved. A number of exciting innovations are emerging, alo......

Micropipette-guided Drug Administration (MDA) as a non-invasive chronic oral administration method in male rats

期刊: JOURNAL OF NEUROSCIENCE METHODS, 2023; 398 ()

Background: In preclinical studies resorting to rodents, the effects of prolonged oral intake of active substances are difficult to evaluate. Indeed, ......

Atraumatic access to human glioblastoma in a xenograft animal model by cerebral open flow microperfusion

期刊: JOURNAL OF NEUROSCIENCE METHODS, 2023; 393 ()

Background: Orthotopic xenograft studies promote the development of targeted/personalized therapies to improve the still poor life expectancy of gliob......

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