期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (23)
Enhancers activate their cognate promoters over huge distances but how enhancer/promoter interactions become established is not completely understood.......
期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (5)
Due to unique features, proline residues may control protein structure and function. Here, we investigated the role of 52PPQ54 residues, indicated by ......
期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (12)
Pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene hyperactivate LRRK2 kinase activity and lead to the development of Parkinson's d......
期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (14)
Prediction of orthologs is an important bioinformatics pursuit that is frequently used for inferring protein function and evolutionary analyses. The I......
期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (8)
The detection of structural chromosomal abnormalities (SCA) is crucial for diagnosis, prognosis and man-agement of many genetic diseases and cancers. ......
期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (12)
Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by several patho-logical features, including selective neuronal los......
期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (16)
The cellular defense against viruses involves the assembly of oligomers, granules and membraneless organelles (MLOs) that govern the activation of sev......
期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (21)
Polymorphic toxins (PTs) are a broad family of toxins involved in interbacterial competition and pathogenesis. PTs are modular proteins that are compr......
期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (2)
Barrier-to-Autointegration Factor (BAF) is a highly conserved DNA binding protein important for genome integrity. Its localization and function are re......
期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (5)
Eukaryotic translation initiation factor 4E (eIF4E) is a key factor involved in different aspects of mRNA metabolism. Drosophila melanogaster genome e......
期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (10)
The neuronal SNARE protein SNAP25a (isoform 2) forms part of the SNARE complex eliciting synaptic vesicle fusion during neuronal exocytosis. While the......
期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (11)
Functional amyloids are a rapidly expanding class of fibrillar protein structures, with a core cross-0 scaffold, where novel and advantageous biologic......
期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (14)
Operons are groups of consecutive genes that transcribe together under the regulation of a common promoter. They influence protein regulation and vari......
期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (12)
Sphingolipids, including the basic ceramide, are a subset of bioactive lipids that consist of many different species. Sphingolipids are indispensable ......
期刊: JOURNAL OF MOLECULAR BIOLOGY, 2023; 435 (14)
G protein coupled receptors (GPCRs) are critical eukaryotic signal transduction gatekeepers and repre-sent the largest protein superfamily in the huma......